647925 Sigma-AldrichTrichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem
Trichostatin A, Streptomyces sp., CAS 58880-19-6, is a cell-permeable, potent, reversible inhibitor of histone deacetylase (IC50 = 6, 38, and 6 nM for HDAC1, 4, and 6, respectively).
More>> Trichostatin A, Streptomyces sp., CAS 58880-19-6, is a cell-permeable, potent, reversible inhibitor of histone deacetylase (IC50 = 6, 38, and 6 nM for HDAC1, 4, and 6, respectively). Less<<Synonyms: 4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, TSA, HDAC Inhibitor IX
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Overview
Key Spec Table
CAS # | Empirical Formula |
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58880-19-6 | C₁₇H₂₂N₂O₃ |
Pricing & Availability
Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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647925-1MG |
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Plastic ampoule | 1 mg |
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Description | |
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Overview | A potent and reversible, cell-permeable inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-transformed NIH/3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC50 = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model. Down-regulates p57kip2 in Hep 3B cells. IC50 = 6 nM for HDAC1; 38 nM for HDAC4, and 8.6 nM for HDAC6A. 10 mM (500 µg/165 µl) solution of Trichostatin A, Streptomyces sp. (Cat. No. 647926) in DMSO is also available. |
Catalogue Number | 647925 |
Brand Family | Calbiochem® |
Synonyms | 4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, TSA, HDAC Inhibitor IX |
Product Information | |
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CAS number | 58880-19-6 |
ATP Competitive | N |
Form | Off-white lyophilized solid |
Hill Formula | C₁₇H₂₂N₂O₃ |
Chemical formula | C₁₇H₂₂N₂O₃ |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Primary Target | histone deactylase |
Primary Target IC<sub>50</sub> | 73 nM inhibiting IL-2 gene expressionin Jurkat cells |
Purity | ≥98% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Safety Information according to GHS | |
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RTECS | MI5215000 |
Global Trade Item Number | |
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Catalogue Number | GTIN |
647925-1MG | 07790788052003 |