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647925 Trichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem

Trichostatin A, Streptomyces sp., CAS 58880-19-6, is a cell-permeable, potent, reversible inhibitor of histone deacetylase (IC50 = 6, 38, and 6 nM for HDAC1, 4, and 6, respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, TSA, HDAC Inhibitor IX

Primary Target: histone deactylase
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647925
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Overview

Key Spec Table

CAS #Empirical Formula
58880-19-6C₁₇H₂₂N₂O₃

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      Description
      OverviewA potent and reversible, cell-permeable inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-transformed NIH/3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC50 = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model. Down-regulates p57kip2 in Hep 3B cells. IC50 = 6 nM for HDAC1; 38 nM for HDAC4, and 8.6 nM for HDAC6A. 10 mM (500 µg/165 µl) solution of Trichostatin A, Streptomyces sp. (Cat. No. 647926) in DMSO is also available.
      Catalogue Number647925
      Brand Family Calbiochem®
      Synonyms4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, TSA, HDAC Inhibitor IX
      References
      ReferencesFurumai, R., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 87.
      Gray, S.G. and Ekstrom, T.J. 1998. Biochem. Biophys. Res. Commun. 245, 423.
      Takahashi, I., et al. 1996. J. Antibiot. 49, 453.
      Taunton, J., et al. 1996. Science 272, 408.
      Futamura, M., et al. 1995. Oncogene 10, 1119.
      Hoshikawa, Y., et al. 1994. Exp. Cell Res. 214, 189.
      Product Information
      CAS number58880-19-6
      ATP CompetitiveN
      FormOff-white lyophilized solid
      Hill FormulaC₁₇H₂₂N₂O₃
      Chemical formulaC₁₇H₂₂N₂O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationTrichostatin A, Streptomyces sp., CAS 58880-19-6, is a cell-permeable, potent, reversible inhibitor of histone deacetylase (IC50 = 6, 38, and 6 nM for HDAC1, 4, and 6, respectively).
      Biological Information
      Primary Targethistone deactylase
      Primary Target IC<sub>50</sub>73 nM inhibiting IL-2 gene expressionin Jurkat cells
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Safety Information according to GHS
      RTECSMI5215000
      Safety Information
      R PhraseR: 20/21/22-36/37/38-43

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      May cause sensitization by skin contact.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). Following reconstitution in ethanol, refrigerate (4°C). DMSO stock solutions are stable for up to 6 months at -20°C. Ethanol stock solutions are stable for up to 3 months at 4°C.
      Global Trade Item Number
      Catalogue Number GTIN
      647925-1MG 07790788052003