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05-23-0600 Substance P - CAS 33507-63-0 - Calbiochem

Neuropeptide found in high concentrations in the gut.

Substance P - CAS 33507-63-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: RPKPQQFFGLM

Primary Target: Substance P receptors
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05-23-0600
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
33507-63-0C₆₃H₉₈N₁₈O₁₃S

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      Description
      OverviewNeuropeptide found in high concentrations in the gut. When released from afferent nerves, causes a neurogenic inflammatory response, including mast cell degranulation. Induces Ca2+ mobilization. Reported to activate Goα, Gq/11α, and Gsα subunits in CHO cells via activation of substance P receptors. Also reported to induce superoxide production in neutrophils.
      Catalogue Number05-23-0600
      Brand Family Calbiochem®
      SynonymsRPKPQQFFGLM
      References
      ReferencesRoush, E.D., and Kwatra, M.M. 1998. FEBS Lett. 428, 291.
      Chiwakata, C.B., et al. 1996. Infect. Immun. 64, 5106.
      Tanabe, T., et al. 1996. Eur. J. Pharmacol. 299, 187.
      Heath, M.J., et al. 1994. J. Neurophysiol. 72, 1192.
      Zhu, J., et al. 1994. Eur. J. Pharmacol. 268, 279.
      Garland, A.M., et al. 1993. Soc. Neurosci. 19, Abstract 104.6.
      Wei, J.Y., et al. 1993. Soc. Neurosci. 19, Abstract 136.14.
      Product Information
      CAS number33507-63-0
      ATP CompetitiveN
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₆₃H₉₈N₁₈O₁₃S
      Chemical formulaC₆₃H₉₈N₁₈O₁₃S
      Hygroscopic Hygroscopic
      ReversibleN
      Sold on the basis of peptide contentY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetSubstance P receptors
      Purity≥96% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide ContentY
      Peptide SequenceH-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      05-23-0600-5MG 04055977207033

      Documentation

      Substance P - CAS 33507-63-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Substance P - CAS 33507-63-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      05-23-0600

      References

      Reference overview
      Roush, E.D., and Kwatra, M.M. 1998. FEBS Lett. 428, 291.
      Chiwakata, C.B., et al. 1996. Infect. Immun. 64, 5106.
      Tanabe, T., et al. 1996. Eur. J. Pharmacol. 299, 187.
      Heath, M.J., et al. 1994. J. Neurophysiol. 72, 1192.
      Zhu, J., et al. 1994. Eur. J. Pharmacol. 268, 279.
      Garland, A.M., et al. 1993. Soc. Neurosci. 19, Abstract 104.6.
      Wei, J.Y., et al. 1993. Soc. Neurosci. 19, Abstract 136.14.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision02-February-2023 JSW
      SynonymsRPKPQQFFGLM
      DescriptionNeuropeptide found in high concentrations in the gut. When released from afferent nerves, causes a neurogenic inflammatory response, including mast cell degranulation. Induces Ca2+ mobilization. Reported to activate Goα, Gq/11α, and Gsα subunits in CHO cells via activation of substance P receptors. Also reported to induce superoxide production in neutrophils.
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      CAS number33507-63-0
      Chemical formulaC₆₃H₉₈N₁₈O₁₃S
      Peptide SequenceH-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH₂
      Purity≥96% by HPLC
      Solubility5% Acetic Acid (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      Merck USA index14, 8863
      ReferencesRoush, E.D., and Kwatra, M.M. 1998. FEBS Lett. 428, 291.
      Chiwakata, C.B., et al. 1996. Infect. Immun. 64, 5106.
      Tanabe, T., et al. 1996. Eur. J. Pharmacol. 299, 187.
      Heath, M.J., et al. 1994. J. Neurophysiol. 72, 1192.
      Zhu, J., et al. 1994. Eur. J. Pharmacol. 268, 279.
      Garland, A.M., et al. 1993. Soc. Neurosci. 19, Abstract 104.6.
      Wei, J.Y., et al. 1993. Soc. Neurosci. 19, Abstract 136.14.