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851009 PyBOP

PyBOP Novabiochem®. CAS 128625-52-5, molar mass 520.39 g/mol.

PyBOP MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 128625-52-5 Molar Mass: 520.39 g/mol Hill Formula: C₁₈H₂₈N₆OP * F₆P
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851009
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Overview

Replacement Information

Key Spec Table

CAS #Hill FormulaMolar Mass
128625-52-5C₁₈H₂₈N₆OP * F₆P520.39 g/mol

Pricing & Availability

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8510090025
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      		 Plastic bottle 25 g
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      8510090100
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          		 Plastic bottle 100 g
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          8510091000
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              		 Plastic bottle 1 kg
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              Description
              Catalogue Number851009
              Replaces01-62-0016
              Brand Family Novabiochem®
              Alternate Names
              • Benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate
              Background InformationThe standard in situ coupling reagent for solid phase peptide synthesis [1-5]. This product can replace BOP in all applications without loss of performance. Unlike uronium-based reagents, PyBOP® does not give rise to guanidinated by-products during cyclization and fragment condensation reactions.

              The product number for this product was previously 01-62-0016.

              To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
              References
              Product Information
              CAS number128625-52-5
              Hill FormulaC₁₈H₂₈N₆OP * F₆P
              Molar Mass520.39 g/mol
              HS Code2933 99 80
              Structure formula ImageStructure formula Image
              Quality LevelMQ400
              Applications
              ApplicationPyBOP Novabiochem®. CAS 128625-52-5, molar mass 520.39 g/mol.
              Biological Information
              Physicochemical Information
              Density1.438 g/cm3 (20 °C)
              Melting Point140 - 155 °C
              Vapor pressure<1 hPa (25 °C)
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Hazard Pictogram(s) Hazard Pictogram(s)
              Hazard Pictogram(s)
              Hazard Statement(s)H302: Harmful if swallowed.
              H317: May cause an allergic skin reaction.
              H410: Very toxic to aquatic life with long lasting effects.
              Precautionary Statement(s)P261: Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
              P264: Wash skin thoroughly after handling.
              P273: Avoid release to the environment.
              P280: Wear protective gloves.
              P301 + P312: IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell.
              P302 + P352: IF ON SKIN: Wash with plenty of water.
              Signal WordWarning
              Storage class10 - 13 Other liquids and solids
              WGKWGK 3 highly hazardous to water
              Safety Information
              Categories of dangerirritant
              Product Usage Statements
              Storage and Shipping Information
              StorageStore at +2°C to +8°C.
              Packaging Information
              Transport Information
              Declaration (railroad and road) ADR, RIDUN 3077 , 9, III
              Declaration (transport by air) IATA-DGRUN 3077 , 9, III
              Declaration (transport by sea) IMDG-CodeUN 3077 , 9, III, Marine Pollutant: P
              Supplemental Information
              Specifications
              Color (visual)white to slight yellow to beige
              Appearance of substance (visual)powder
              Identity (IR)passes test
              Assay (HPLC, area%)≥ 99.0 % (a/a)
              Solubility (1 mmole in 2 ml DMF)clearly soluble
              Global Trade Item Number
              Catalogue Number GTIN
              8510090025 04027269081089
              8510090100 04027269081096
              8510091000 04027269131296

              Documentation

              PyBOP SDS

              Title

              Safety Data Sheet (SDS) 

              PyBOP Certificates of Analysis

              Product Number PackagingSpecificationLot Number
              8510090025 Plastic bottlePDF Specification Document
              8510090100 Plastic bottlePDF Specification Document
              8510091000 Plastic bottlePDF Specification Document

              Brochure

              Title
              Novabiochem Coupling Reagent Flyer 2010
              Novabiochem Innovations 02/06
              Novabiochem Innovations 03/10
              Novabiochem Letters 01/14

              Citations

              Title
              • [1] J. Martinez, et al. (1985) J. Med. Chem., 28, 1874.
              • [2] J. Coste, et al. (1990) Tetrahedron Lett., 31, 205.
              • [3] G. B. Fields, et al. in 'Innovation & Perspectives in Solid Phase Synthesis, 1st International Symposium', R. Epton (Eds), SPCC UK Ltd., Birmingham, 1990, pp. 241.
              • [4] T. Høeg-Jensen, et al. (1991) Tetrahedron Lett., 32, 7617.
              • [5] R. von Eggelkraut-Gottanka, et al. (2003) Tetrahedron Lett., 44, 3551.