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506132 Pifithrin-α - CAS 63208-82-2 - Calbiochem

A cell-permeable chemical inhibitor of p53.

Pifithrin-α - CAS 63208-82-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone, HBr

Primary Target: PS3
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506132
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
63208-82-2C₁₆H₁₈N₂OS·HBr

Pricing & Availability

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506132-10MG
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      		 Plastic ampoule 10 mg
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      Description
      OverviewA cell-permeable chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Protects normal tissues from the deleterious side effects of chemotherapy. Has been reported to protect neurons against β-amyloid peptide and glutamate-induced apoptosis.
      Catalogue Number506132
      Brand Family Calbiochem®
      Synonyms2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone, HBr
      References
      ReferencesMurphy, P.J.M., et al. 2004. J. Biol. Chem. 279, 30195.
      Culmsee, C., et al. 2001. J. Neurochem. 77, 220.
      Komarova, E.A., and Gudkov, A.V. 2000. Biochemistry (Mosc.) 65, 41.
      Stadler, P., et al. 2000. Strahlenther Onkol. 176, 98.
      Ferber, D. 1999. Science 285, 1651.
      Jacquemin-Sablon, A. 1999. Bull. Cancer 86, 894.
      Komarov, P.G., et al. 1999. Science 285, 1733.
      Product Information
      CAS number63208-82-2
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₆H₁₈N₂OS·HBr
      Chemical formulaC₁₆H₁₈N₂OS·HBr
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPS3
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot into cold tubes and freeze (-20°C). Stock solutions in DMSO are stable for 3 months at -20°C. Unstable in aqueous solutions.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      506132-10MG 04055977199499

      Documentation

      Pifithrin-α - CAS 63208-82-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Pifithrin-α - CAS 63208-82-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      506132

      References

      Reference overview
      Murphy, P.J.M., et al. 2004. J. Biol. Chem. 279, 30195.
      Culmsee, C., et al. 2001. J. Neurochem. 77, 220.
      Komarova, E.A., and Gudkov, A.V. 2000. Biochemistry (Mosc.) 65, 41.
      Stadler, P., et al. 2000. Strahlenther Onkol. 176, 98.
      Ferber, D. 1999. Science 285, 1651.
      Jacquemin-Sablon, A. 1999. Bull. Cancer 86, 894.
      Komarov, P.G., et al. 1999. Science 285, 1733.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      p53 And Related Products
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-April-2008 RFH
      Synonyms2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone, HBr
      DescriptionA reversible inhibitor of p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Protects mice from lethal genotoxic stress associated with anticancer treatment without promoting tumor formation. Has been reported to protect neurons against β-amyloid and glutamate-induced apoptosis.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number63208-82-2
      Chemical formulaC₁₆H₁₈N₂OS·HBr
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot into cold tubes and freeze (-20°C). Stock solutions in DMSO are stable for 3 months at -20°C. Unstable in aqueous solutions.
      Toxicity Standard Handling
      ReferencesMurphy, P.J.M., et al. 2004. J. Biol. Chem. 279, 30195.
      Culmsee, C., et al. 2001. J. Neurochem. 77, 220.
      Komarova, E.A., and Gudkov, A.V. 2000. Biochemistry (Mosc.) 65, 41.
      Stadler, P., et al. 2000. Strahlenther Onkol. 176, 98.
      Ferber, D. 1999. Science 285, 1651.
      Jacquemin-Sablon, A. 1999. Bull. Cancer 86, 894.
      Komarov, P.G., et al. 1999. Science 285, 1733.