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52332 Phenylmethylsulfonyl Fluoride - CAS 329-98-6 - Calbiochem

Phenylmethylsulfonyl Fluoride, CAS 329-98-6, is an irreversible inhibitor of serine proteases. It causes sulfonylation of the active-site serine residues.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Benzylsulfonyl Fluoride, PMSF

Primary Target: serine proteases
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
329-98-6C₇H₇FO₂S

Pricing & Availability

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52332-25GM
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      52332-5GM
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          		 Glass bottle 5 gm
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          Description
          OverviewIrreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. For a related, more stable inhibitor, see AEBSF (Cat. No. 101500).
          Catalogue Number52332
          Brand Family Calbiochem®
          SynonymsBenzylsulfonyl Fluoride, PMSF
          References
          ReferencesSeitz, R., et al. 1993. Int. J. Cancer 53, 514.
          Weaver, V.M., et al. 1993. Biochem. Cell. Biol. 71, 488.
          Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol. 316, 427.
          Chang, C.T., et al. 1992. Biochem. Int. 28, 707.
          Product Information
          CAS number329-98-6
          ATP CompetitiveN
          FormWhite to off-white crystalline solid
          Hill FormulaC₇H₇FO₂S
          Chemical formulaC₇H₇FO₂S
          Reconstitutiont½ = 1 hour at pH 7.5. Effective concentration: 50 μM.
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ200
          Applications
          Biological Information
          Primary Targetserine proteases
          Purity≥99% by GC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSXT8040000
          Safety Information
          R PhraseR: 34

          Causes burns.
          S PhraseS: 26-36/37/39-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Corrosive
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +15°C to +30°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 9 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          52332-25GM 04055977271508
          52332-5GM 04055977271515

          Documentation

          Phenylmethylsulfonyl Fluoride - CAS 329-98-6 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Phenylmethylsulfonyl Fluoride - CAS 329-98-6 - Calbiochem Certificates of Analysis

          TitleLot Number
          52332

          References

          Reference overview
          Seitz, R., et al. 1993. Int. J. Cancer 53, 514.
          Weaver, V.M., et al. 1993. Biochem. Cell. Biol. 71, 488.
          Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol. 316, 427.
          Chang, C.T., et al. 1992. Biochem. Int. 28, 707.

          Brochure

          Title
          Caspases and other Apoptosis Related Tools Brochure

          Citations

          Title
        • Sun, G., et al. 2007. Journal of Bacteriology 189, 6222.
          		•
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision19-August-2008 RFH
          SynonymsBenzylsulfonyl Fluoride, PMSF
          DescriptionIrreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. Effective at a concentration of 50 µM.
          FormWhite to off-white crystalline solid
          CAS number329-98-6
          RTECSXT8040000
          Chemical formulaC₇H₇FO₂S
          Structure formulaStructure formula
          Purity≥99% by GC
          SolubilityEthanol, isopropanol, or methanol
          Storage Protect from moisture
          +15°C to +30°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 9 months at 4°C.
          Toxicity Corrosive
          ReferencesSeitz, R., et al. 1993. Int. J. Cancer 53, 514.
          Weaver, V.M., et al. 1993. Biochem. Cell. Biol. 71, 488.
          Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol. 316, 427.
          Chang, C.T., et al. 1992. Biochem. Int. 28, 707.
          Citation
        • Sun, G., et al. 2007. Journal of Bacteriology 189, 6222.
          		•