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399275 Nω-Hydroxy-nor-L-arginine, Diacetate Salt - CAS 189302-40-7 - Calbiochem

Nω-Hydroxy-nor-L-arginine, Diacetate Salt, CAS 189302-40-7, is a potent, selective, competitive, and high affinity inhibitor of arginase (IC50 = 2 µM for rat liver and 50 µM for mouse macrophages).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: nor-NOHA, 2CH₃CO₂H, L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH₃CO₂H

Primary Target: arginase from rat liver
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399275
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
189302-40-7C₅H₁₂N₄O₃ · 2CH₃CO₂H

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      Description
      OverviewA potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC50 = 2 µM) and mouse macrophages (IC50 = 50 µM). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.
      Catalogue Number399275
      Brand Family Calbiochem®
      Synonymsnor-NOHA, 2CH₃CO₂H, L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH₃CO₂H
      References
      ReferencesGobert, A.P., et al. 2000. Infect. Immun. 68, 4653.
      Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
      Moali, C., et al. 2000. Biochemistry 39, 8208.
      Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
      Moali, C., et al. 1998. Biochemistry 37, 10453.
      Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.
      Product Information
      CAS number189302-40-7
      FormOff-white solid
      Hill FormulaC₅H₁₂N₄O₃ · 2CH₃CO₂H
      Chemical formulaC₅H₁₂N₄O₃ · 2CH₃CO₂H
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationNω-Hydroxy-nor-L-arginine, Diacetate Salt, CAS 189302-40-7, is a potent, selective, competitive, and high affinity inhibitor of arginase (IC50 = 2 µM for rat liver and 50 µM for mouse macrophages).
      Biological Information
      Primary Targetarginase from rat liver
      Primary Target IC<sub>50</sub>2 µM
      Secondary targetmouse macrophages (IC₅₀ = 50 µM)
      Purity≥97% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      399275-5MG 07790788049881

      Documentation

      Nω-Hydroxy-nor-L-arginine, Diacetate Salt - CAS 189302-40-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Nω-Hydroxy-nor-L-arginine, Diacetate Salt - CAS 189302-40-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      399275

      References

      Reference overview
      Gobert, A.P., et al. 2000. Infect. Immun. 68, 4653.
      Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
      Moali, C., et al. 2000. Biochemistry 39, 8208.
      Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
      Moali, C., et al. 1998. Biochemistry 37, 10453.
      Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.

      Brochure

      Title
      Pathways and Biomarkers of Oxidative Stress
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-October-2007 JSW
      Synonymsnor-NOHA, 2CH₃CO₂H, L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH₃CO₂H
      DescriptionA potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC50 = 2 µM) and mouse macrophages (IC50 = 50 µM). Specifically interacts with the manganese-cluster of the enzyme active site. Does not act as a substrate or as an inhibitor of NOS. Hence, it may serve as a useful tool to study the interplays between arginase and NOS.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number189302-40-7
      Chemical formulaC₅H₁₂N₄O₃ · 2CH₃CO₂H
      Structure formulaStructure formula
      Purity≥97% by TLC
      SolubilityH₂O (50 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesGobert, A.P., et al. 2000. Infect. Immun. 68, 4653.
      Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
      Moali, C., et al. 2000. Biochemistry 39, 8208.
      Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
      Moali, C., et al. 1998. Biochemistry 37, 10453.
      Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.