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108396 L-Tryptophan

EMPROVE® EXPERT Ph Eur,BP,JP,USP

L-Tryptophan MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Trp

CAS #: 73-22-3 EC Number: 200-795-6 Molar Mass: 204.23 g/mol Hill Formula: C₁₁H₁₂N₂O₂ Grade: Ph Eur,BP,JP,USP
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108396
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Overview

Replacement Information

Key Spec Table

CAS #EC NumberHill FormulaMolar MassGrade Value
73-22-3200-795-6C₁₁H₁₂N₂O₂204.23 g/molPh Eur,BP,JP,USP

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1083961000
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      1083969010
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          Description
          Catalogue Number108396
          SynonymsTrp
          References
          Product Information
          CAS number73-22-3
          EC number200-795-6
          GradePh Eur,BP,JP,USP
          Hill FormulaC₁₁H₁₂N₂O₂
          Molar Mass204.23 g/mol
          HS Code2933 99 99
          Structure formula ImageStructure formula Image
          Quality LevelMQ500
          Applications
          Biological Information
          Physicochemical Information
          Melting Point290 °C (decomposition)
          pH value5.5 - 7 (1 g/l, H₂O, 25 °C)
          Bulk density400 kg/m3
          Solubility10 g/l
          Dimensions
          Materials Information
          Toxicological Information
          LD 50 oralLD50 Rat 16000 mg/kg
          Safety Information according to GHS
          RTECSYN6130000
          Storage class10 - 13 Other liquids and solids
          WGKWGK 1 slightly hazardous to water
          Disposal3
          Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          StorageStore at +2°C to +30°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Assay (perchloric acid titration, calculated on dried substance)98.5 - 101.0 %
          Identity (IR-spectrum)passes test
          Identity (specific rotation)passes test
          Appearancewhite to almost white, crystalline or amorphous powder
          Appearance of solution (10 g/l, Hydrochloric acid 1 mol/l)clear and not more intense in color than reference solution BY₆
          Appearance of solution (20 g/l, hydrochloric acid 2 mol/l)clear
          pH (10 g/l, CO₂-free water)5.5 - 6.4
          Spec. rotation (α 20/D, 10 g/l, water, calc. on dried substance)-30.0 to -33.0
          Spec. rotation (α 25/D, 10 g/l, water, calc. on dried substance)-29.4 to -32.8
          Spec. rotation (α 20/D, 10 g/l, water, previously dried substance)-30.0 to -33.0
          Chloride (Cl)≤ 200 ppm
          Sulfate (SO₄)≤ 200 ppm
          Heavy metals (as Pb)≤ 20 ppm
          Fe (Iron)≤ 20 ppm
          As (Arsenic)≤ 2 ppm
          Ninhydrin-positive substances (LC) (any ninhydrin-positive impurity)≤ 0.2 %
          Ninhydrin-positive substances (LC) (ammonium (570 nm))≤ 0.02 %
          Ninhydrin-positive substances (LC) (total impurities)≤ 0.5 %
          Related substances (HPLC)passes test
          Impurity A ((1,1‘-ethylidenebistryptophan) Peak-E) (acc. to Ph Eur)≤ 10 ppm
          Sum of impurities with RT < tryptophan-peak (acc. to Ph Eur)≤ 100 ppm
          Sum of impurities with RT > tryptophan-peak and up to1,8 times the RT ofacetyltryptophan (acc. to Ph Eur)≤ 300 ppm
          Impurity A ((1,1‘-ethylidenebistryptophan) Peak-E) (acc. to USP)≤ 10 ppm
          Sum of impurities with RT < tryptophan-peak (acc. to USP)≤ 100 ppm
          Sum of impurities with RT > tryptophan-peak, without tryptophan-peak andpeak of „Related Compound B“ (N-acetyltryptophan) (acc. to USP)≤ 300 ppm
          Related substances (TLC)passes test
          Residual solvents (ICH (Q3C))excluded by manufacturing process
          Sulfated ash (600 °C)≤ 0.1 %
          Loss on drying (105 °C; 3 h)≤ 0.30 %
          Bacterial endotoxins≤ 10 I.U./g
          Microbiological test (total aerobic microbial count (TAMC))≤ 100 CFU/g
          Microbiological test (total yeast and mould count (TYMC))≤ 100 CFU/g
          Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
          Corresponds to Ph. Eur., BP, JP, USP.
          Global Trade Item Number
          Catalogue Number GTIN
          1083961000 04022536104003
          1083969010 04022536732701

          Documentation

          Material Qualification Dossier

          TitleVersion
          9.0

          Quality Management Dossier (Open Access)

          Title

          Operational Excellence Dossier

          Title

          L-Tryptophan SDS

          Title

          Safety Data Sheet (SDS) 

          L-Tryptophan Certificates of Analysis

          Product Number PackagingSpecificationLot Number
          1083961000 Plastic bottlePDF Specification Document
          1083969010 Plastic drumPDF Specification Document

          Certificates

          Title