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407950 Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem

Ionomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is an ionophore with high specificity for divalent cations. More effective than A23187 as a mobile ion carrier for Ca2+.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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407950
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
56092-81-0C₄₁H₇₂O₉

Pricing & Availability

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407950-10MG
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      407950-5MG
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          Description
          OverviewHighly specific for divalent cations and more effective than A23187 (Cat. No. 100105) as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5. In contrast to A23187, it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest in the G1 phase in mature Burkitt lymphoma cell lines.
          Absorption max. (280 nm, MeOH): 18,600 M-1cm-1.
          Catalogue Number407950
          Brand Family Calbiochem®
          References
          ReferencesAagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
          Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
          Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
          Lee, H.C. 1993. J. Biol. Chem. 268, 293.
          Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
          Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
          Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.
          Product Information
          CAS number56092-81-0
          ATP CompetitiveN
          FormWaxy solid
          Hill FormulaC₄₁H₇₂O₉
          Chemical formulaC₄₁H₇₂O₉
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationIonomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is an ionophore with high specificity for divalent cations. More effective than A23187 as a mobile ion carrier for Ca2+.
          Biological Information
          Primary TargetMobile ion carrier for Ca2+
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSNO0600000
          Safety Information
          R PhraseR: 22

          Harmful if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 year at 4°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          407950-10MG 04055977211566
          407950-5MG 04055977211573

          Documentation

          Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem Certificates of Analysis

          TitleLot Number
          407950

          References

          Reference overview
          Aagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
          Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
          Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
          Lee, H.C. 1993. J. Biol. Chem. 268, 293.
          Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
          Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
          Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.

          Brochure

          Title
          Caspases and other Apoptosis Related Tools Brochure

          Citations

          Title
        • Jonathan Rios-Doria, et al. (2004) Cleavage of b-catenin by calpain in prostate and mammary tumor cells. Cancer Research 64, 7237-7240.
          		•
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-April-2010 JSW
          DescriptionHighly specific for divalent cations (Ca2+ > Mg2+ >> Sr2+ = Ba2+). More effective than antibiotic A23187 as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5, causing significant absorption in the UV range; however, in contrast to A23187 (Cat. No. 100105), it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons. Also induces cell cycle arrest in the G1 interval of mature Burkitt lymphoma cell lines.
          FormWaxy solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number56092-81-0
          RTECSNO0600000
          Chemical formulaC₄₁H₇₂O₉
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO (10 mg/ml) and Methanol (10 mg/ml)
          Storage Protect from light
          +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 year at 4°C.
          Toxicity Harmful
          ReferencesAagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
          Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
          Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
          Lee, H.C. 1993. J. Biol. Chem. 268, 293.
          Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
          Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
          Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.
          Citation
        • Jonathan Rios-Doria, et al. (2004) Cleavage of b-catenin by calpain in prostate and mammary tumor cells. Cancer Research 64, 7237-7240.
          		•

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Biochemicals > Ionophores