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565784 InSolution™ γ-Secretase Inhibitor IX - Calbiochem

InSolution™ g-Secretase Inhibitor IX, CAS 208255-80-5, is a 25 mM (5 mg/462 µl or 10 mg/924 µl) solution of g-secretase Inhibitor IX (DAPT; Cat. No. 565770) in DMSO.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, DAPT

Primary Target: Aβtotal
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565784
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₃H₂₆F₂N₂O₄

Pricing & Availability

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565784-5MG
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      Description
      Catalogue Number565784
      Brand Family Calbiochem®
      SynonymsN-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, DAPT
      References
      ReferencesOddo, S., et al. 2004. Neuron 43, 321.
      Dovey, H.F., et al. 2001. J. Neurochem. 76, 173.
      Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.
      Product Information
      ATP CompetitiveN
      FormClear colorless liquid
      FormulationA 25 mM (5 mg/462 µl or 10 mg/924 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565770) in DMSO.
      Hill FormulaC₂₃H₂₆F₂N₂O₄
      Chemical formulaC₂₃H₂₆F₂N₂O₄
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAβtotal
      Primary Target IC<sub>50</sub>115 nM, 200 nM against Aβtotal, Aβ42, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      565784-5MG 04055977191806

      Documentation

      InSolution™ γ-Secretase Inhibitor IX - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ γ-Secretase Inhibitor IX - Calbiochem Certificates of Analysis

      TitleLot Number
      565784

      References

      Reference overview
      Oddo, S., et al. 2004. Neuron 43, 321.
      Dovey, H.F., et al. 2001. J. Neurochem. 76, 173.
      Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.

      Citations

      Title
    • Yunzhou Dong, et al. (2006) Calpain inhibitor MDL28170 modulates Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation. FASEB Journal in press,.
    • Yasuhiko Kawakami, et al. (2005) Retinoic acid signalling links leftright asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature 435, 165-171.
    • Aurelie Olivier, et al. (2005) The Notch ligand delta-1 is a hematopoietic development co- factor for plasmacytoid dendritic cells. Blood 107, 2694-2701.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-January-2013 JSW
      SynonymsN-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, DAPT
      DescriptionA cell-permeable dipeptide that inhibits γ-secretase activity and suppresses Aβ production (Aβ total IC50 = 115 nM; Aβ42 IC50 = 200 nM). Reported to be functionally active in both HEK293 cells overexpressing human APP751 and neuronal cultures, however, it does not affect the secretion of amyloid-b precursor protein (APP). Effective in acutely lowering Ab in APPV717F-transgenic mice. Also effective in inhibiting the production of a ~6 kDa C-terminal cleavage product (CTFg) in HEK293 cells stably transfected with the Swedish mutant, βAPP695. Reported to reduce extracellular Aβ plaques and intracellular Aβ accumulation in 3xTgAD transgenic mice.
      FormClear colorless liquid
      FormulationA 25 mM (5 mg/462 µl or 10 mg/924 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565770) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₃H₂₆F₂N₂O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and freeze (-20°C).
      Toxicity Irritant
      ReferencesOddo, S., et al. 2004. Neuron 43, 321.
      Dovey, H.F., et al. 2001. J. Neurochem. 76, 173.
      Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.
      Citation
    • Yunzhou Dong, et al. (2006) Calpain inhibitor MDL28170 modulates Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation. FASEB Journal in press,.
    • Yasuhiko Kawakami, et al. (2005) Retinoic acid signalling links leftright asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature 435, 165-171.
    • Aurelie Olivier, et al. (2005) The Notch ligand delta-1 is a hematopoietic development co- factor for plasmacytoid dendritic cells. Blood 107, 2694-2701.
      		•