Millipore Sigma Vibrant Logo

238803 Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem

The Cdk2 Inhibitor III, also referenced under CAS 199986-75-9, controls the biological activity of Cdk2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine, CVT-313

Primary Target: Cdk2/A, Cdk2/E
View Products on Sigmaaldrich.com
238803
View Pricing & Availability

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
199986-75-9C₂₀H₂₈N₆O₃

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
238803-1MG
Retrieving availability...
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Plastic ampoule 1 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      Description
      OverviewA cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC50 = 0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1). Inhibits other kinases only at much higher concentrations (IC50 > 1.25 mM for MAPK, PKA, and PKC). Shown to induce tumor cells growth arrest (IC50 = ~1.25-20 µM) in vitro and prevent neointima formation in vivo.
      Catalogue Number238803
      Brand Family Calbiochem®
      Synonyms2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine, CVT-313
      References
      ReferencesBhattacharjee, R.N., et al. 2001. Mol. Cell. Biol. 21, 5417.
      Brooks, E.E., et al. 1997. J. Biol. Chem. 272, 29207.
      Product Information
      CAS number199986-75-9
      ATP CompetitiveY
      DeclarationSold under license of U.S. Patents 6,617,331 and 6,803,371.
      FormWhite to off-white solid
      Hill FormulaC₂₀H₂₈N₆O₃
      Chemical formulaC₂₀H₂₈N₆O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCdk2/A, Cdk2/E
      Primary Target IC<sub>50</sub>0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      238803-1MG 04055977216608

      Documentation

      Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      238803

      References

      Reference overview
      Bhattacharjee, R.N., et al. 2001. Mol. Cell. Biol. 21, 5417.
      Brooks, E.E., et al. 1997. J. Biol. Chem. 272, 29207.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-October-2020 JSW
      Synonyms2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine, CVT-313
      DescriptionA cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC50 = 0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1). Inhibits other kinases only at much higher concentrations (IC50 > 1.25 mM for MAPK, PKA, and PKC). Shown to induce tumor cells growth arrest (IC50 ~1.25-20 µM) in vitro and prevent neointima formation in vivo.
      FormWhite to off-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number199986-75-9
      Chemical formulaC₂₀H₂₈N₆O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesBhattacharjee, R.N., et al. 2001. Mol. Cell. Biol. 21, 5417.
      Brooks, E.E., et al. 1997. J. Biol. Chem. 272, 29207.