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218759 Caspase-8 Inhibitor II - Calbiochem

Caspase-8 Inhibitor II, CAS 210344-98-2, is a potent, cell-permeable, irreversible inhibitor of caspase-8 and granzyme B.

Caspase-8 Inhibitor II - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-IE(OMe)TD(OMe)-FMK, Granzyme B Inhibitor III

Primary Target: caspase-8
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218759
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₃₀H₄₃FN₄O₁₁

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
218759-250UG
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      		 Glass bottle 250 μg
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      Description
      OverviewA potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218840) in DMSO is also available.
      Catalogue Number218759
      Brand Family Calbiochem®
      SynonymsZ-IE(OMe)TD(OMe)-FMK, Granzyme B Inhibitor III
      References
      ReferencesTakizawa, T., et al. 1999. Microbiol. Immunol. 43, 245.
      Martin, D.A., et al. 1998. J. Biol. Chem. 273, 4345.
      Sweeney, E.A., et al. 1998. FEBS Lett. 425, 61.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Product Information
      ATP CompetitiveN
      FormWhite to yellow powder
      Hill FormulaC₃₀H₄₃FN₄O₁₁
      Chemical formulaC₃₀H₄₃FN₄O₁₁
      ReversibleN
      Quality LevelMQ100
      Applications
      ApplicationCaspase-8 Inhibitor II, CAS 210344-98-2, is a potent, cell-permeable, irreversible inhibitor of caspase-8 and granzyme B.
      Biological Information
      Primary Targetcaspase-8
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 8 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      218759-250UG 04055977218626

      Documentation

      Caspase-8 Inhibitor II - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Caspase-8 Inhibitor II - Calbiochem Certificates of Analysis

      TitleLot Number
      218759

      References

      Reference overview
      Takizawa, T., et al. 1999. Microbiol. Immunol. 43, 245.
      Martin, D.A., et al. 1998. J. Biol. Chem. 273, 4345.
      Sweeney, E.A., et al. 1998. FEBS Lett. 425, 61.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure

      Citations

      Title
    • Sinead M. Miggin, et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Procedings of the National Academy of Science 104, 3372-3377.
    • Kira Steigerwald, et al. (2005) The APC tumor suppressor promotes transcription-independent apoptosis in vitro. Molecular Cancer Research 3, 78-89.
    • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
    • Ashish K. Sharma and Baerbel Rohrer. (2004) Calcium-induced Calpain Mediates Apoptosis via Caspase-3 in a Mouse Photoreceptor Cell Line. Journal of Biological Chemistry 279, 35564-35572.
    • Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-November-2023 JSW
      SynonymsZ-IE(OMe)TD(OMe)-FMK, Granzyme B Inhibitor III
      DescriptionA potent, cell-permeable, and irreversible inhibitor of caspase-8 (MACH, FLICE, Mch5). Also inhibits granzyme B.
      FormWhite to yellow powder
      Chemical formulaC₃₀H₄₃FN₄O₁₁
      Peptide SequenceZ-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*
      Purity≥98% by HPLC
      SolubilityDMSO (10 mM)
      Storage Protect from moisture
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 8 months at -20°C.
      Toxicity Standard Handling
      ReferencesTakizawa, T., et al. 1999. Microbiol. Immunol. 43, 245.
      Martin, D.A., et al. 1998. J. Biol. Chem. 273, 4345.
      Sweeney, E.A., et al. 1998. FEBS Lett. 425, 61.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Citation
    • Sinead M. Miggin, et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Procedings of the National Academy of Science 104, 3372-3377.
    • Kira Steigerwald, et al. (2005) The APC tumor suppressor promotes transcription-independent apoptosis in vitro. Molecular Cancer Research 3, 78-89.
    • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
    • Ashish K. Sharma and Baerbel Rohrer. (2004) Calcium-induced Calpain Mediates Apoptosis via Caspase-3 in a Mouse Photoreceptor Cell Line. Journal of Biological Chemistry 279, 35564-35572.
    • Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.
      		•