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235425 Caspase-3 Substrate II, Fluorogenic - CAS 169332-61-0 - Calbiochem

Fluorogenic caspase-3 substrate.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ac-DEVD-AMC

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235425
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Overview

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      Description
      OverviewFluorogenic caspase-3 substrate. Cleavage of this substrate by caspase-3 shows Michaelis-Menten kinetics (Km = 9.7 ± 1.0 µM). Also a substrate for caspase-6, caspase-7, caspase-8, and caspase-10.
      Catalogue Number235425
      Brand Family Calbiochem®
      SynonymsAc-DEVD-AMC
      References
      ReferencesHermission, M., et al. 2000. Oncogene 19, 2338.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Nicholson, D.W., et al. 1995. Nature 376, 37.
      Product Information
      CAS number169332-61-0
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₃₀H₃₇N₅O₁₃
      Chemical formulaC₃₀H₃₇N₅O₁₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFluorogenic caspase-3 substrate
      Primary Target IC<sub>50</sub>Km = 9.7 ± 1.0 µM for cleavage of this substrate by caspase-3
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Emission max.
      Excitation max.
      Peptide SequenceAc-Asp-Glu-Val-Asp-AMC
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      235425-1MG 04055977217032

      Documentation

      Caspase-3 Substrate II, Fluorogenic - CAS 169332-61-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Caspase-3 Substrate II, Fluorogenic - CAS 169332-61-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      235425

      References

      Reference overview
      Hermission, M., et al. 2000. Oncogene 19, 2338.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Nicholson, D.W., et al. 1995. Nature 376, 37.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-March-2011 RFH
      SynonymsAc-DEVD-AMC
      DescriptionFluorogenic CPP32/Apopain substrate. Cleavage of this substrate by CPP32/Apopain shows Michaelis-Menten kinetics (Km = 9.7 ± 1.0 µM). Cleavage can be monitored by excitation at 380 nm and emission at 460 nm.
      FormOff-white solid
      CAS number169332-61-0
      Chemical formulaC₃₀H₃₇N₅O₁₃
      Peptide SequenceAc-Asp-Glu-Val-Asp-AMC
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mM)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHermission, M., et al. 2000. Oncogene 19, 2338.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Nicholson, D.W., et al. 1995. Nature 376, 37.