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264155 Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem

Caspase-3 Inhibitor II, CAS 210344-95-9, is a cell-permeable, potent, and irreversible inhibitor of caspase-3 (IC50 = 130 nM). Also inhibits caspase-6, caspase-7, caspase-8, and caspase-10.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-D(OMe)E(Ome)VD(OMe)-FMK

Primary Target: caspase-3, caspase-6, caspase-7, caspase-8, caspase-10
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264155
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
210344-95-9C₃₀H₄₁FN₄O₁₂

Pricing & Availability

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264155-250UG
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      		 Plastic ampoule 250 μg
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      Description
      OverviewA potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/75 µl) solution of Z-DEVD-FMK (Cat. No. 264156) in DMSO is also available.
      Catalogue Number264155
      Brand Family Calbiochem®
      SynonymsZ-D(OMe)E(Ome)VD(OMe)-FMK
      References
      ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
      Nicholson, D.W. 1996. Nature Biotech. 14, 297.
      Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
      Nicholson, D.W., et al. 1995. Nature 376, 37.
      Product Information
      CAS number210344-95-9
      ATP CompetitiveN
      FormWhite to slightly brown solid
      Hill FormulaC₃₀H₄₁FN₄O₁₂
      Chemical formulaC₃₀H₄₁FN₄O₁₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      ApplicationCaspase-3 Inhibitor II, CAS 210344-95-9, is a cell-permeable, potent, and irreversible inhibitor of caspase-3 (IC50 = 130 nM). Also inhibits caspase-6, caspase-7, caspase-8, and caspase-10.
      Biological Information
      Primary Targetcaspase-3, caspase-6, caspase-7, caspase-8, caspase-10
      Purity≥90% by TLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      264155-250UG 04055977198454

      Documentation

      Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      264155

      References

      Reference overview
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
      Nicholson, D.W. 1996. Nature Biotech. 14, 297.
      Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
      Nicholson, D.W., et al. 1995. Nature 376, 37.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure

      Citations

      Title
    • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-March-2011 RFH
      SynonymsZ-D(OMe)E(Ome)VD(OMe)-FMK
      DescriptionA potent, cell-permeable and irreversible inhibitor of CPP-32/apopain, a member of the ICE/CED-3 family of cysteine proteases.
      FormWhite to slightly brown solid
      CAS number210344-95-9
      Chemical formulaC₃₀H₄₁FN₄O₁₂
      Peptide SequenceZ-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK
      Structure formulaStructure formula
      Purity≥90% by TLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from moisture
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
      Nicholson, D.W. 1996. Nature Biotech. 14, 297.
      Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
      Nicholson, D.W., et al. 1995. Nature 376, 37.
      Citation
    • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.
      		•