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03-34-0051 Calpeptin - CAS 117591-20-5 - Calbiochem

Calpeptin, CAS 117591-20-5, is a cell-permeable inhibitor of calpain 1 and 2 (ID50 = 52 nM for calpain-1; and 34 nM for calpain-2) and papain (ID50 = 138 nM)

Calpeptin - CAS 117591-20-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Benzyloxycarbonylleucyl-norleucinal

Primary Target: Calpain-1
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03-34-0051
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
117591-20-5C₂₀H₃₀N₂O₄

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      03-34-0051-5MG
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          Description
          OverviewA cell-permeable calpain inhibitor (ID50 = 52 nM for calpain-1; ID50 = 34 nM for calpain-2; ID50 = 138 nM for papain). Inhibits the Ca2+-stimulated cleavage of p35 to p25 by calpain. Modulates the processing of β-amyloid precursor protein to β-amyloid (Aβ). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore-induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells.
          Catalogue Number03-34-0051
          Brand Family Calbiochem®
          SynonymsBenzyloxycarbonylleucyl-norleucinal
          References
          ReferencesLee, M.S., et al. 2000. Nature 405, 360.
          Yamazaki, T., et al. 1997. Biochemistry 27, 8377.
          Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
          Shiba, E., et al. 1996. Anticancer Res. 16, 773.
          Pinter, M., et al. 1994. Neurosci. Lett. 170, 91.
          Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231.
          Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.
          Product Information
          CAS number117591-20-5
          ATP CompetitiveN
          FormWhite to off-white solid
          Hill FormulaC₂₀H₃₀N₂O₄
          Chemical formulaC₂₀H₃₀N₂O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationCalpeptin, CAS 117591-20-5, is a cell-permeable inhibitor of calpain 1 and 2 (ID50 = 52 nM for calpain-1; and 34 nM for calpain-2) and papain (ID50 = 138 nM)
          Biological Information
          Primary TargetCalpain-1
          Primary Target IC<sub>50</sub>ID50 = 52 nM for calpain-1; 34 nM for calpain-2; 138 nM for papain
          Purity≥94% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceZ-Leu-Nle-CHO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          03-34-0051-25MG 04055977206845
          03-34-0051-5MG 04055977206852

          Documentation

          Calpeptin - CAS 117591-20-5 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Calpeptin - CAS 117591-20-5 - Calbiochem Certificates of Analysis

          TitleLot Number
          03-34-0051

          References

          Reference overview
          Lee, M.S., et al. 2000. Nature 405, 360.
          Yamazaki, T., et al. 1997. Biochemistry 27, 8377.
          Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
          Shiba, E., et al. 1996. Anticancer Res. 16, 773.
          Pinter, M., et al. 1994. Neurosci. Lett. 170, 91.
          Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231.
          Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.

          Citations

          Title
        • Rosenberger, G., et al. 2005. Journal of Biological Chemistry 280, 6879.
        • Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.
          		•
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-October-2007 JSW
          SynonymsBenzyloxycarbonylleucyl-norleucinal
          DescriptionA cell-permeable calpain inhibitor. Inactivates calpain I (ID50 = 52 nM), calpain II (ID50 = 34 nM), and papain (ID50 = 138 nM). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells.
          FormWhite to off-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number117591-20-5
          Chemical formulaC₂₀H₃₀N₂O₄
          Peptide SequenceZ-Leu-Nle-CHO
          Structure formulaStructure formula
          Purity≥94% by HPLC
          SolubilityDMF (5 mg/ml) or DMSO (5 mg/ml). Dissolve in a minimal amount of DMF or DMSO then add H₂O, buffer or medium just prior to use.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Standard Handling
          ReferencesLee, M.S., et al. 2000. Nature 405, 360.
          Yamazaki, T., et al. 1997. Biochemistry 27, 8377.
          Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
          Shiba, E., et al. 1996. Anticancer Res. 16, 773.
          Pinter, M., et al. 1994. Neurosci. Lett. 170, 91.
          Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231.
          Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.
          Citation
        • Rosenberger, G., et al. 2005. Journal of Biological Chemistry 280, 6879.
        • Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.
          		•