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124011 Akt Inhibitor IV - CAS 681281-88-9 - Calbiochem

Akt Inhibitor IV, CAS 681281-88-9, is a cell permeable, reversible inhibitor of Akt phosphorylation that targets the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Akt
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124011
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
681281-88-9C₃₁H₂₇IN₄S

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124011-1MG
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      Description
      OverviewA cell permeable and reversible benzimidazole compound that inhibits Akt phosphorylation/activation by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K. Shown to block Akt-mediated FOXO1a nuclear export (IC50 = 625 nM) and cell proliferation (IC50 <1.25 µM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3K. A 10 mM (1 mg/163 µl) solution of Akt Inhibitor IV (Cat. No. 124015) in DMSO is also available.
      Catalogue Number124011
      Brand Family Calbiochem®
      References
      ReferencesKau, T.R., et al. 2003. Cancer Cell 4, 463.



      Selected Citations
      Lee, J., et al. 2009. Cell Stem Cell 5, 76.
      Product Information
      CAS number681281-88-9
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₃₁H₂₇IN₄S
      Chemical formulaC₃₁H₂₇IN₄S
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationAkt Inhibitor IV, CAS 681281-88-9, is a cell permeable, reversible inhibitor of Akt phosphorylation that targets the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K.
      Biological Information
      Primary TargetAkt
      Primary Target IC<sub>50</sub>625 nM in blocking Akt-mediated FOXO1a nuclear export; < 1.25 µM in blocking Akt-mediated cell proliferation in 786-O cells
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      124011-1MG 04055977206357

      Documentation

      Akt Inhibitor IV - CAS 681281-88-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      124011

      References

      Reference overview
      Kau, T.R., et al. 2003. Cancer Cell 4, 463.



      Selected Citations
      Lee, J., et al. 2009. Cell Stem Cell 5, 76.

      Brochure

      Title
      Akt
      Biologics 31.1

      Posters

      Title
      Human Kinome & InhibitorSelect™ Libraries

      Citations

      Title
    • Chengyu Wu and Jiaoti Huang. (2007) Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer. Journal of Biological Chemistry 282, 3571-3583.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-November-2009 RFH
      DescriptionA cell-permeable and reversible benzimidazole compound that inhibits Akt phosphorylation/activation presumably by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3-K. Shown to block Akt-mediated FOXO1a nuclear export (IC50 = 625 nM) and cell proliferation (IC50 <1.25 µM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3-K.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number681281-88-9
      Chemical formulaC₃₁H₂₇IN₄S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKau, T.R., et al. 2003. Cancer Cell 4, 463.



      Selected Citations
      Lee, J., et al. 2009. Cell Stem Cell 5, 76.
      Citation
    • Chengyu Wu and Jiaoti Huang. (2007) Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer. Journal of Biological Chemistry 282, 3571-3583.
      		•