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28745 Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem

This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Dibutyryl-cAMP, Na

Primary Target: PKA
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28745
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
16980-89-5C₁₈H₂₃N₅O₈P · Na

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28745-25MG
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      Description
      OverviewA cell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (PKA). Causes an increase in the steady state level of parathyroid hormone-related peptide mRNA. Also acts as a Hh pathway antagonist. Shown to induce apoptosis in vascular smooth muscle cells.
      Catalogue Number28745
      Brand Family Calbiochem®
      SynonymsDibutyryl-cAMP, Na
      References
      ReferencesNoveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
      Tsai, C.H., et al. 1995. J. Cell. Physiol. 164, 108.
      Leszczynski, D., et al. 1994. Am. J. Pathol. 145, 1265.
      Miller, C., et al. 1994. J. Neurosci. Res. 38, 56.
      Hinko, A., and Soloff, M.S. 1993. Endocrinology 132, 126.
      Ikeda, K., et al. 1993. J. Biol. Chem. 268, 1174.
      Park, E.A., et al. 1993. J. Biol. Chem. 268, 613.
      Hei, Y-J., et al. 1991. Mol. Pharmacol. 39, 233.
      Posternak, T., and Weimann, G. 1974. Methods Enzymol. 38, 399.
      Product Information
      CAS number16980-89-5
      ATP CompetitiveN
      FormWhite lyophilized solid
      Hill FormulaC₁₈H₂₃N₅O₈P · Na
      Chemical formulaC₁₈H₂₃N₅O₈P · Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      Biological Information
      Primary TargetPKA
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSES5055500
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions are stable for up to 3 days at 4°C or for up to 3 months at -20°C. Avoid pH >8.5.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      28745-25MG 04055977090970

      Documentation

      Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      28745

      References

      Reference overview
      Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
      Tsai, C.H., et al. 1995. J. Cell. Physiol. 164, 108.
      Leszczynski, D., et al. 1994. Am. J. Pathol. 145, 1265.
      Miller, C., et al. 1994. J. Neurosci. Res. 38, 56.
      Hinko, A., and Soloff, M.S. 1993. Endocrinology 132, 126.
      Ikeda, K., et al. 1993. J. Biol. Chem. 268, 1174.
      Park, E.A., et al. 1993. J. Biol. Chem. 268, 613.
      Hei, Y-J., et al. 1991. Mol. Pharmacol. 39, 233.
      Posternak, T., and Weimann, G. 1974. Methods Enzymol. 38, 399.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-March-2008 JSW
      SynonymsDibutyryl-cAMP, Na
      DescriptionCell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (PKA). Known to cause an increase in the steady state level of the parathyroid hormone related peptide mRNA. Also acts as a Hh pathway antagonist. Shown to induce apoptosis in vascular smooth muscle cells.
      FormWhite lyophilized solid
      CAS number16980-89-5
      RTECSES5055500
      Chemical formulaC₁₈H₂₃N₅O₈P · Na
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions are stable for up to 3 days at 4°C or for up to 3 months at -20°C. Avoid pH >8.5.
      Toxicity Standard Handling
      ReferencesNoveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
      Tsai, C.H., et al. 1995. J. Cell. Physiol. 164, 108.
      Leszczynski, D., et al. 1994. Am. J. Pathol. 145, 1265.
      Miller, C., et al. 1994. J. Neurosci. Res. 38, 56.
      Hinko, A., and Soloff, M.S. 1993. Endocrinology 132, 126.
      Ikeda, K., et al. 1993. J. Biol. Chem. 268, 1174.
      Park, E.A., et al. 1993. J. Biol. Chem. 268, 613.
      Hei, Y-J., et al. 1991. Mol. Pharmacol. 39, 233.
      Posternak, T., and Weimann, G. 1974. Methods Enzymol. 38, 399.