Qty	Catalogue Number	Ordering Description	Qty/Pack	List Price
			96-Well Plate

Qty	Catalogue Number	Ordering Description	Qty/Pack	List Price
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

100105 Sigma-AldrichA23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem

A mobile ion-carrier that forms stable complexes with divalent cations.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Brochures
Data Sheet

Synonyms: Calcimycin

Recommended Products

Overview

Replacement Information

Key Spec Table

CAS #	Empirical Formula
52665-69-7	C₂₉H₃₇N₃O₆

Pricing & Availability

Catalogue Number	Availability	Packaging	Qty/Pack	Price	Quantity
100105-5MG	Retrieving availability... — Limited Availability In Stock Discontinued Limited Quantities Available Availability to be confirmed Login to See Inventory In Stock Limited Availability In Stock Remaining : Will advise Remaining : Will advise Will advise Contact Customer Service Contact Customer Service Contact Customer Service Contact Customer Service	Plastic ampoule	5 mg	Retrieving price... Price could not be retrieved Minimum Quantity is a multiple of Maximum Quantity is Upon Order Completion More Information You Saved () — Request Pricing Login to See Your Pricing	Check Availability —	Add To Favorites Add To Favorites Added To My Favorites

Description
Overview	A mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca²⁺ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram-positive bacteria. Also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.
Catalogue Number	100105
Brand Family	Calbiochem®
Synonyms	Calcimycin

References
References	Caron-Leslie, L.A., et al. 1994. FASEB J. 8, 639. Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943. Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501. Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007. Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.

Product Information
CAS number	52665-69-7
ATP Competitive	N
Form	White solid
Hill Formula	C₂₉H₃₇N₃O₆
Chemical formula	C₂₉H₃₇N₃O₆
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Mitochondrial ATPase
Purity	≥98% by TLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	DM4676000

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Catalogue Number	GTIN
100105-5MG	04055977226249

Documentation

A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem SDS

Title
Safety Data Sheet (SDS)

A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem Certificates of Analysis

Title	Lot Number
100105	Enter Lot Number

References

Reference overview
Caron-Leslie, L.A., et al. 1994. FASEB J. 8, 639. Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943. Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501. Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007. Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Tools and Tips for Analyzing Apoptosis

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	07-April-2008 RFH
Synonyms	Calcimycin
Description	A mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca²⁺ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram positive bacteria. Also induces apoptosis in mouse lymphoma cell line (S49); however, A23187 has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells.
Form	White solid
CAS number	52665-69-7
RTECS	DM4676000
Chemical formula	C₂₉H₃₇N₃O₆
Structure formula
Purity	≥98% by TLC
Solubility	DMSO or Methanol. For use in aqueous systems, preparation of a 100 mM stock in DMSO is recommended. Microliter amounts of this solution can then be added to H₂O with rapid mixing (e.g. 10 µl into 5 ml of H₂O). In aqueous systems, the ionophore aggregates over time.
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity	Standard Handling
Merck USA index	14, 1639
References	Caron-Leslie, L.A., et al. 1994. FASEB J. 8, 639. Saunders, M.J., and Hepler, P.K. 1982. Science 217, 943. Pressman, B.C. 1976. Annu. Rev. Biochem. 45, 501. Pfeiffer, D.R., et al. 1974. Biochemistry 13, 4007. Reed, P.W., and Lardy, H.A. 1972. J. Biol. Chem. 247, 6970.

Related Products

Catalogue Number

Description

407950

Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem

Show Pricing & Availability

The Product Has Been Added To Your Cart