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441251 α₂-Macroglobulin, Human Plasma - Calbiochem

A multifunctional, secreted glycoprotein that acts as a broad range irreversible protease inhibitor that forms a "trap" around most proteases.

α₂-Macroglobulin, Human Plasma - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: α₂M, α₂MG

Primary Target: broad range protease
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441251
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Overview

Replacement Information

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441251-10MG
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      Description
      OverviewA multifunctional, secreted glycoprotein that acts as a broad range irreversible protease inhibitor that forms a "trap" around most proteases. α2M is so large a molecule that it tends to remain intravascular. Localized on the surface of peripheral blood lymphocytes. Multifunctional activities include promoting growth of mammalian cells in culture, stimulating regeneration of lymphocytes in irradiated mice, transporting zinc, and acting as proteinase inhibitor that controls the clotting and fibrinolytic system.
      Catalogue Number441251
      Brand Family Calbiochem®
      Synonymsα₂M, α₂MG
      References
      ReferencesBonner, J.C., et al. 1995. J. Biol. Chem. 270, 16236.
      Lysiak, J.J., et al. 1995. J. Biol. Chem. 270, 21919.
      Boisset, N., et al. 1992. J. Struct. Biol. 108, 221.
      Barrett, A.J. 1980. Methods Enzymol. 80, 737.
      Product Information
      ATP CompetitiveN
      FormLyophilized
      FormulationLyophilized from 30 mM sodium phosphate buffer, with glycine, pH 7.0.
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetbroad range protease
      Purity≥95% by SDS-PAGE
      SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      441251-10MG 04055977206005

      Documentation

      α₂-Macroglobulin, Human Plasma - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      α₂-Macroglobulin, Human Plasma - Calbiochem Certificates of Analysis

      TitleLot Number
      441251

      References

      Reference overview
      Bonner, J.C., et al. 1995. J. Biol. Chem. 270, 16236.
      Lysiak, J.J., et al. 1995. J. Biol. Chem. 270, 21919.
      Boisset, N., et al. 1992. J. Struct. Biol. 108, 221.
      Barrett, A.J. 1980. Methods Enzymol. 80, 737.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-August-2008 RFH
      Synonymsα₂M, α₂MG
      DescriptionA multifunctional, secreted glycoprotein that acts as a broad range irreversible protease inhibitor that forms a "trap" around most proteases. α2M is so large a molecule that it tends to remain intravascular. Localized on the surface of peripheral blood lymphocytes. Multifunctional activities include promoting growth of mammalian cells in culture, stimulating regeneration of lymphocytes in irradiated mice, transporting zinc, and acting as proteinase inhibitor that controls the clotting and fibrinolytic system.
      FormLyophilized
      FormulationLyophilized from 30 mM sodium phosphate buffer, with glycine, pH 7.0.
      SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Purity≥95% by SDS-PAGE
      SolubilityAqueous buffers
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBonner, J.C., et al. 1995. J. Biol. Chem. 270, 16236.
      Lysiak, J.J., et al. 1995. J. Biol. Chem. 270, 21919.
      Boisset, N., et al. 1992. J. Struct. Biol. 108, 221.
      Barrett, A.J. 1980. Methods Enzymol. 80, 737.