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487910 (±)-S-Nitroso-N-acetylpenicillamine - CAS 79032-48-7 - Calbiochem

Nitric oxide donor that mimics the actions of nitric oxide, including relaxation of isolated bovine coronary artery rings (EC₅₀ = 130 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: SNAP

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487910
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
79032-48-7C₇H₁₂N₂O₄S

Pricing & Availability

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487910-20MG
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      		 Plastic ampoule 20 mg
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      Description
      OverviewNitric oxide donor that mimics the actions of nitric oxide, including relaxation of isolated bovine coronary artery rings (EC50 = 130 nM). Markedly activates soluble guanylate cyclase. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.
      Catalogue Number487910
      Brand Family Calbiochem®
      SynonymsSNAP
      References
      ReferencesNishio, E., et al. 1996. Biochem. Biophys. Res. Commun. 221, 163.
      Askew, S.C., et al. 1995. Bioorg. Med. Chem. 3, 1.
      Fehsel, K., et al. 1995. J. Immunol. 155, 2858.
      Gopalkrishna, R., et al. 1993. J. Biol. Chem. 268, 27180.
      Southan, E., and Garthwaite, J. 1991. Neurosci. Lett. 130, 107.
      Henry, P.J., et al. 1989. J. Pharmacol. Exp. Ther. 248, 762.
      Product Information
      CAS number79032-48-7
      ATP CompetitiveN
      FormPale green solid
      Hill FormulaC₇H₁₂N₂O₄S
      Chemical formulaC₇H₁₂N₂O₄S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNitric oxide donor
      Primary Target IC<sub>50</sub>EC50 = 130 nM in relaxation of isolated bovine coronary artery rings
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsSNAP evolves NO immediately upon solubilization; reconstitute just prior to use.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      487910-20MG 04055977200331

      Documentation

      (±)-S-Nitroso-N-acetylpenicillamine - CAS 79032-48-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      (±)-S-Nitroso-N-acetylpenicillamine - CAS 79032-48-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      487910

      References

      Reference overview
      Nishio, E., et al. 1996. Biochem. Biophys. Res. Commun. 221, 163.
      Askew, S.C., et al. 1995. Bioorg. Med. Chem. 3, 1.
      Fehsel, K., et al. 1995. J. Immunol. 155, 2858.
      Gopalkrishna, R., et al. 1993. J. Biol. Chem. 268, 27180.
      Southan, E., and Garthwaite, J. 1991. Neurosci. Lett. 130, 107.
      Henry, P.J., et al. 1989. J. Pharmacol. Exp. Ther. 248, 762.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure

      Citations

      Title
    • Bysani Chandrasekar, et al. (2005) The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-J. Journal of Biological Chemistry 280, 26263-26277.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-October-2016 JSW
      SynonymsSNAP
      DescriptionNitric oxide donor that begins to evolve nitric oxide immediately upon solubilization in aqueous buffers (t1/2 = 10 h). Mimics the actions of nitric oxide, including the relaxation of isolated bovine coronary artery rings (EC50 = 130 nM). Markedly activates soluble guanylate cyclase. Also reported to cause the reversible inactivation of protein kinase C activity. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.
      FormPale green solid
      CAS number79032-48-7
      Chemical formulaC₇H₁₂N₂O₄S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (25 mg/ml), Ethanol (25 mg/ml), or Methanol
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsSNAP evolves NO immediately upon solubilization; reconstitute just prior to use.
      Toxicity Irritant
      ReferencesNishio, E., et al. 1996. Biochem. Biophys. Res. Commun. 221, 163.
      Askew, S.C., et al. 1995. Bioorg. Med. Chem. 3, 1.
      Fehsel, K., et al. 1995. J. Immunol. 155, 2858.
      Gopalkrishna, R., et al. 1993. J. Biol. Chem. 268, 27180.
      Southan, E., and Garthwaite, J. 1991. Neurosci. Lett. 130, 107.
      Henry, P.J., et al. 1989. J. Pharmacol. Exp. Ther. 248, 762.
      Citation
    • Bysani Chandrasekar, et al. (2005) The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-J. Journal of Biological Chemistry 280, 26263-26277.
      		•