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506181 p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 - Calbiochem

p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5, acts as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in dorsal root ganglion & postnatal cerebellar neurons.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: TAT-Pep5, H-YGRKKRRQRRR-CFFRGGFFNHNPRYC-OH, Cyclic

Primary Target: Blocker of MAG- and Nogo-induced inhibition of neurite outgrowth
506181
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Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₁₅₀H₂₂₇N₅₇O₃₂S₂

Products

RéférenceConditionnement Qté
506181-500UG Ampoule plast. 500 μg
Description
OverviewThe p75NTR inhibitor Pep5 (Cat. No. 506180) is made cell-permeable by fusing it with the N-terminal protein transduction domain sequence (11 amino acids) from HIV protein TAT. Shown to act as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in both DRG (dorsal root ganglion) and postnatal cerebellar neurons. A potential therapeutic agent against inhibition of regeneration in the central nervous system.
Catalogue Number506181
Brand Family Calbiochem®
SynonymsTAT-Pep5, H-YGRKKRRQRRR-CFFRGGFFNHNPRYC-OH, Cyclic
References
ReferencesYamashita, T., and Tohyama, M. 2003. Nat. Neurosci. 6, 461.
Schwarze, S.R., et al. 1999. Science 285, 1569.
Product Information
ATP CompetitiveN
FormLyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₅₀H₂₂₇N₅₇O₃₂S₂
Chemical formulaC₁₅₀H₂₂₇N₅₇O₃₂S₂
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Applicationp75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5, acts as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in dorsal root ganglion & postnatal cerebellar neurons.
Biological Information
Primary TargetBlocker of MAG- and Nogo-induced inhibition of neurite outgrowth
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceH₂N-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys¹²-Phe-Phe-Arg-Gly-Gly-Phe-Phe-Asn-His-Asn-Pro-Arg-Tyr-Cys²⁶-OH
disulfide bond (12-26)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
506181-500UG 04055977272413

Documentation

p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 - Calbiochem Certificats d'analyse

TitreNuméro de lot
506181

Références bibliographiques

Aperçu de la référence bibliographique
Yamashita, T., and Tohyama, M. 2003. Nat. Neurosci. 6, 461.
Schwarze, S.R., et al. 1999. Science 285, 1569.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-August-2008 RFH
SynonymsTAT-Pep5, H-YGRKKRRQRRR-CFFRGGFFNHNPRYC-OH, Cyclic
DescriptionThe p75NTR inhibitor Pep5 (Cat. No. 506180) fused to the N-terminal, 11-amino acid protein transduction domain sequence from the HIV TAT protein for membrane permeability. Show to inhibit the association of p75NTR with Rho-GDI in vitro. Reported to act as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in dorsal root ganglion (DRG) and postnatal cerebellar neurons at a concentration of 100 nM. Reported to be a potential therapeutic agent for the inhibition of regeneration in the central nervous system.
FormLyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₅₀H₂₂₇N₅₇O₃₂S₂
Peptide SequenceH₂N-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys¹²-Phe-Phe-Arg-Gly-Gly-Phe-Phe-Asn-His-Asn-Pro-Arg-Tyr-Cys²⁶-OH
disulfide bond (12-26)
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesYamashita, T., and Tohyama, M. 2003. Nat. Neurosci. 6, 461.
Schwarze, S.R., et al. 1999. Science 285, 1569.