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506149 p53 Activator III, RITA - CAS 213261-59-7 - Calbiochem

The p53 Activator III, RITA, also referenced under CAS 213261-59-7, modulates the biological activity of p53. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: NSC 652287, 2,5-bis-(5-Hydroxymethyl-2-thienyl)-furan, Reactivation of p53 and Induction of Tumor cell Apoptosis, MDM2 Antagonist VII, MDM2 Inhibitor X

Primary Target: p53
506149
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
213261-59-7C₁₄H₁₂O₃S₂

Products

RéférenceConditionnement Qté
506149-1MG Ampoule plast. 1 mg
Description
OverviewA cell-permeable, p53-targeting, tricyclic thiophene derivative that displays antitumor properties. Blocks p53—MDM2 interaction and p53 ubiquitination and induces p53-dependent apoptosis in tumor cells expressing wild-type p53. Shown to restore the tumor suppressor function of p53 by inducing its accumulation in HCT116 colon carcinoma cells (~0.1 µM) and in p53-positive SCID mice xenografted with HCT116 cells (0.1, 1 or 10 mg/kg, ip) in vivo.
Catalogue Number506149
Brand Family Calbiochem®
SynonymsNSC 652287, 2,5-bis-(5-Hydroxymethyl-2-thienyl)-furan, Reactivation of p53 and Induction of Tumor cell Apoptosis, MDM2 Antagonist VII, MDM2 Inhibitor X
References
ReferencesGrinkevich, V., et al. 2005. Nat. Med. 11, 1136.
Krajewski, M., et al. 2005. Nat. Med. 11, 1135.
Issaeva, N., et al. 2004. Nat. Med. 10, 1321.
Nieves-Neira, W., et al. 1999. Mol. Pharmacol. 56, 478.
Rivera, M.I., et al. 1999. Biochem. Pharmacol. 57, 1283.
Product Information
CAS number213261-59-7
ATP CompetitiveN
FormCrystalline solid
Hill FormulaC₁₄H₁₂O₃S₂
Chemical formulaC₁₄H₁₂O₃S₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetp53
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
506149-1MG 07790788050870

Documentation

p53 Activator III, RITA - CAS 213261-59-7 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

p53 Activator III, RITA - CAS 213261-59-7 - Calbiochem Certificats d'analyse

TitreNuméro de lot
506149

Références bibliographiques

Aperçu de la référence bibliographique
Grinkevich, V., et al. 2005. Nat. Med. 11, 1136.
Krajewski, M., et al. 2005. Nat. Med. 11, 1135.
Issaeva, N., et al. 2004. Nat. Med. 10, 1321.
Nieves-Neira, W., et al. 1999. Mol. Pharmacol. 56, 478.
Rivera, M.I., et al. 1999. Biochem. Pharmacol. 57, 1283.

Brochure

Titre
Interactive Pathway Calendar
p53 And Related Products
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-August-2008 RFH
SynonymsNSC 652287, 2,5-bis-(5-Hydroxymethyl-2-thienyl)-furan, Reactivation of p53 and Induction of Tumor cell Apoptosis, MDM2 Antagonist VII, MDM2 Inhibitor X
DescriptionA cell-permeable, p53-targeting, tricyclic thiophene derivative that displays antitumor properties. Blocks p53—MDM2 interaction and p53 ubiquitination and induces p53-dependent apoptosis in tumor cells expressing wild-type p53. Shown to restore the tumor suppressor function of p53 by inducing its accumulation in HCT116 colon carcinoma cells (~0.1 µM) and in p53-positive SCID mice xenografted with HCT116 cells (0.1, 1 or 10 mg/kg, ip) in vivo.
FormCrystalline solid
Intert gas (Yes/No) Packaged under inert gas
CAS number213261-59-7
Chemical formulaC₁₄H₁₂O₃S₂
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (3 mg/ml) or Ethanol (1 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesGrinkevich, V., et al. 2005. Nat. Med. 11, 1136.
Krajewski, M., et al. 2005. Nat. Med. 11, 1135.
Issaeva, N., et al. 2004. Nat. Med. 10, 1321.
Nieves-Neira, W., et al. 1999. Mol. Pharmacol. 56, 478.
Rivera, M.I., et al. 1999. Biochem. Pharmacol. 57, 1283.