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530538 cPLA2α Inhibitor II, Pyrrophenone - CAS 341973-06-6 - Calbiochem

A cell-permeable, highly potent, and reversible inhibitor of cytosolic phospholipase A2a (IC₅₀ = 4.2 nM).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Phospholipase A2α Inhibitor

Primary Target: PLA2a
530538
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
341973-06-6C₄₉H₃₇F₂N₃O₅S₂

Products

RéférenceConditionnement Qté
5305380001 Flacon en verre 1 mg
Description
OverviewA cell-permeable, non-toxic, pyrolidine derivative that acts as a highly potent, and reversible inhibitor of cytosolic phospholipase A2a (cPLA2a; IC50 = 4.2 nM). Does not inhibit the activities of PLA IB and IIA groups even at higher concentrations (~250 µM). Unlike AACOCF3 (Cat. No. 100109), its action is shown to be rapid and does not require a pre-incubation period. Diminishes the release of arachidonic acid (IC50 = 24 nM), prostaglandin E2 (PGE2; IC50 = 25 nM) and leukotriene C4 (IC50 = 14 nM) in A23187 stimulated THP-1 cells. Its effects on production of PGE2 and thromboxane B2 are comparable to those of indomethacin. Also shown to inhibit the lysophospholipase and esterase activity of cPLA2&alpha.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number530538
Brand Family Calbiochem®
SynonymsPhospholipase A2α Inhibitor
References
ReferencesOno, T., et al. 2002. Biochem. J. 363, 727.
Seno, K., et al. 2001. Bioorg. Med. Chem. Lett. 11, 587.
Product Information
CAS number341973-06-6
FormOff-white powder
Hill FormulaC₄₉H₃₇F₂N₃O₅S₂
Chemical formulaC₄₉H₃₇F₂N₃O₅S₂
Quality LevelMQ100
Applications
Biological Information
Primary TargetPLA2a
Primary Target IC<sub>50</sub>4.2 nM
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
5305380001 04055977260892

Documentation

cPLA2α Inhibitor II, Pyrrophenone - CAS 341973-06-6 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Références bibliographiques

Aperçu de la référence bibliographique
Ono, T., et al. 2002. Biochem. J. 363, 727.
Seno, K., et al. 2001. Bioorg. Med. Chem. Lett. 11, 587.

Brochure

Titre
NPI Flyer- Epigenetics and Nuclear Function Feature
New Products - Antibodies, Small Molecule, Inhibitors

Informations techniques

Titre
White Paper: Further considerations of antibody validation and usage.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-October-2014 JSW
SynonymsPhospholipase A2α Inhibitor
DescriptionA cell-permeable, non-toxic, pyrolidine derivative that acts as a highly potent, and reversible inhibitor of cytosolic phospholipase A2a (cPLA2a; IC50 = 4.2 nM). Does not inhibit the activities of PLA IB and IIA groups even at higher concentrations (~250 µM). Unlike AACOCF3 (Cat. No. 100109), its action is shown to be rapid and does not require a pre-incubation period. Diminishes the release of arachidonic acid (IC50 = 24 nM), prostaglandin E2 (PGE2; IC50 = 25 nM) and leukotriene C4 (IC50 = 14 nM) in A23187 stimulated THP-1 cells. Its effects on production of PGE2 and thromboxane B2 are comparable to those of indomethacin. Also shown to inhibit the lysophospholipase and esterase activity of cPLA2&alpha.
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number341973-06-6
Chemical formulaC₄₉H₃₇F₂N₃O₅S₂
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesOno, T., et al. 2002. Biochem. J. 363, 727.
Seno, K., et al. 2001. Bioorg. Med. Chem. Lett. 11, 587.