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681673 Wnt Antagonist III, Box5 - Calbiochem

681673
Purchase on Sigma-Aldrich

Aperçu

Tableau de caractéristiques principal

Empirical Formula
C₃₀H₅₀N₆O₁₃S₂

Products

RéférenceConditionnement Qté
681673-10MG Flacon en verre 10 mg
Description
OverviewA Wnt-5a-derived, N-terminally butyloxycarbonyl- (Boc) protected, hexa-peptide that effectively antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration, invasion, calcium response, and MARCKS phosphorylation. Replacing the N-terminal Boc with a formyl modification results in a peptide termed Foxy5 that mimics, instead of antagonizes, Wnt-5a biological activity in a Frizzled-5- (Fzd-5/Frz-5) dependent manner. The peptide sequence is conserved in multiple species, including human, mouse, and rat, and Box5 is expected to exert its effect via direct FZD5 binding as is the case with Foxy5.
Catalogue Number681673
Brand Family Calbiochem®
SynonymsWnt-5a Antagonist, Wnt Pathway Inhibitor VI, Boc-MDGCEL-OH, Frizzled-5 Antagonist
References
ReferencesJenei, V., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 19473.
Safholm, A., et al. 2006. J. Biol. Chem. 281, 2740.
Product Information
FormWhite lyophilized solid
Hill FormulaC₃₀H₅₀N₆O₁₃S₂
Chemical formulaC₃₀H₅₀N₆O₁₃S₂
Quality LevelMQ100
Applications
ApplicationWnt Antagonist III, Box5, is a Wnt-5a-derived hexapeptide that antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration and invasion.
Biological Information
Purity≥90% by HPLC
Physicochemical Information
Peptide Sequencet-Boc-NH-Met-Asp-Gly-Cys-Glu-Leu-CO₂H
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Référence GTIN
681673-10MG 04055977225211