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681535 Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem

A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Primary Target: A steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.
681535
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
5119-48-2C₂₈H₃₈O₆

Products

RéférenceConditionnement Qté
681535-1MG Ampoule plast. 1 mg
681535-5MG Ampoule plast. 5 mg
Description
OverviewA cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits angiogenesis both in vitro (IC50 = 12 nM against HUVEC proliferation) and in vivo (80% inhibition at 7 µg/kg/day in C57BL/6J mice, s.c.) and NF-κB activation (IC50 = 500 nM in TNF-α-induced endothelial cells) by targeting the ubiquitin-mediated proteasome pathway. At higher concentrations (~5 µM) also affects AP-1 transcription and induces cell death.
Catalogue Number681535
Brand Family Calbiochem®
References
ReferencesMohan, R., et al. 2004. Angiogenesis 7, 115.
Jeyaprakasam, B., et al. 2003. Life Sci. 74, 125.
Devi, P.U., et al. 1995. Cancer Lett. 95, 189.
Kupchan, S.M., et al. 1969. J. Org. Chem. 34, 3858.
Product Information
CAS number5119-48-2
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₈H₃₈O₆
Chemical formulaC₂₈H₃₈O₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetA steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.
Primary Target IC<sub>50</sub>12 nM against angiogenesis in vitro by inhibiting HUVEC proliferation
Purity≥94% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSKE7288500
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
681535-1MG 04055977260113
681535-5MG 04055977260120

Documentation

Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem Certificats d'analyse

TitreNuméro de lot
681535

Références bibliographiques

Aperçu de la référence bibliographique
Mohan, R., et al. 2004. Angiogenesis 7, 115.
Jeyaprakasam, B., et al. 2003. Life Sci. 74, 125.
Devi, P.U., et al. 1995. Cancer Lett. 95, 189.
Kupchan, S.M., et al. 1969. J. Org. Chem. 34, 3858.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-September-2008 RFH
DescriptionA cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits angiogenesis both in vitro (IC50 = 12 nM against HUVEC proliferation) and in vivo (80% inhibition at 7 µg/kg/day in C57BL/6J mice, s.c.) and NF-κB activation (IC50 = 500 nM in TNF-α-induced endothelial cells) by targeting the ubiquitin-mediated proteasome pathway. At higher concentrations (~5 µM) also affects AP-1 transcription and induces cell death.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number5119-48-2
RTECSKE7288500
Chemical formulaC₂₈H₃₈O₆
Structure formulaStructure formula
Purity≥94% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesMohan, R., et al. 2004. Angiogenesis 7, 115.
Jeyaprakasam, B., et al. 2003. Life Sci. 74, 125.
Devi, P.U., et al. 1995. Cancer Lett. 95, 189.
Kupchan, S.M., et al. 1969. J. Org. Chem. 34, 3858.