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681500 WHI-P180

A potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo.

WHI-P180 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 4-(3ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline

Primary Target: Cdk2
681500
Purchase on Sigma-Aldrich

Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
211555-08-7C₁₆H₁₅N₃O₃

Products

RéférenceConditionnement Qté
681500-1MG Ampoule plast. 1 mg
Description
OverviewA potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo. Also inhibits cyclin-dependent kinase 2 (Cdk2; IC50 = 1 µM) by blocking the ATP site.
Catalogue Number681500
Brand Family Calbiochem®
Synonyms4-(3ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline
References
ReferencesShewchuk, L., et al. 2000. J. Med. Chem. 43, 133.
Chen, C.L., et al. 1999. Pharm. Res. 16, 117.
Product Information
CAS number211555-08-7
ATP CompetitiveN
FormPale yellow solid
Hill FormulaC₁₆H₁₅N₃O₃
Chemical formulaC₁₆H₁₅N₃O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCdk2
Primary Target IC<sub>50</sub>1 µM for Cdk2
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
681500-1MG 04055977260687

Documentation

WHI-P180 FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

WHI-P180 Certificats d'analyse

TitreNuméro de lot
681500

Références bibliographiques

Aperçu de la référence bibliographique
Shewchuk, L., et al. 2000. J. Med. Chem. 43, 133.
Chen, C.L., et al. 1999. Pharm. Res. 16, 117.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-June-2009 RFH
Synonyms4-(3ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline
DescriptionA potent inhibitor of IgE-mediated mast cell responses to allergens in vitro and in vivo. Also inhibits cyclin-dependent kinase 2 (Cdk2; IC50 = 1 µM) by blocking the ATP site.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number211555-08-7
Chemical formulaC₁₆H₁₅N₃O₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesShewchuk, L., et al. 2000. J. Med. Chem. 43, 133.
Chen, C.L., et al. 1999. Pharm. Res. 16, 117.