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681625 W-5, Hydrochloride - CAS 61714-25-8 - Calbiochem

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 230 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC₅₀ = 240 µM).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N-(6-Aminohexyl)-1-naphthalenesulfonamide, HCl

Primary Target: Myosin light chain kinase (Mlck)
681625
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
61714-25-8C₁₆H₂₂N₂O₂S · HCl

Products

RéférenceConditionnement Qté
681625-1MG Ampoule plast. 1 mg
Description
OverviewA cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 230 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 µM).
Catalogue Number681625
Brand Family Calbiochem®
SynonymsN-(6-Aminohexyl)-1-naphthalenesulfonamide, HCl
References
ReferencesTanaka, T., et al. 1983. Pharmacol. 26, 249.
Asano, M., et al. 1982. J. Pharmacol. Exp. Ther. 220, 191.
Hidaka, H. 1981. Prot. Nuc. Acid Enz. 26, 977.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.
Product Information
CAS number61714-25-8
ATP CompetitiveN
FormCrystalline solid
Hill FormulaC₁₆H₂₂N₂O₂S · HCl
Chemical formulaC₁₆H₂₂N₂O₂S · HCl
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMyosin light chain kinase (Mlck)
Primary Target IC<sub>50</sub>230 µM and 240 µM against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase, respectively.
Purity≥98% by NMR
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
681625-1MG 04055977260137

Documentation

W-5, Hydrochloride - CAS 61714-25-8 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

W-5, Hydrochloride - CAS 61714-25-8 - Calbiochem Certificats d'analyse

TitreNuméro de lot
681625

Références bibliographiques

Aperçu de la référence bibliographique
Tanaka, T., et al. 1983. Pharmacol. 26, 249.
Asano, M., et al. 1982. J. Pharmacol. Exp. Ther. 220, 191.
Hidaka, H. 1981. Prot. Nuc. Acid Enz. 26, 977.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-January-2010 RFH
SynonymsN-(6-Aminohexyl)-1-naphthalenesulfonamide, HCl
DescriptionA cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 µM) and myosin light chain kinase (IC50 = 230 µM).
FormCrystalline solid
CAS number61714-25-8
Chemical formulaC₁₆H₂₂N₂O₂S · HCl
Structure formulaStructure formula
Purity≥98% by NMR
SolubilityDMSO or H₂O
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Toxicity Standard Handling
ReferencesTanaka, T., et al. 1983. Pharmacol. 26, 249.
Asano, M., et al. 1982. J. Pharmacol. Exp. Ther. 220, 191.
Hidaka, H. 1981. Prot. Nuc. Acid Enz. 26, 977.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.

Produits & Applications associés

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Catégories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Phosphodiesterase Inhibitors
Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Myosin Light Chain Kinase (MLCK) Inhibitors