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681636 W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 58 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC₅₀ = 68 µM).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide, HCl

Primary Target: mlck
681636
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
88519-57-7C₁₄H₁₇ClN₂O₂S . HCl

Products

RéférenceConditionnement Qté
681636-1MG Ampoule plast. 1 mg
Description
OverviewA cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 58 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 68 µM).
Catalogue Number681636
Brand Family Calbiochem®
SynonymsN-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide, HCl
References
ReferencesHidaka, H., and Tanaka, T. 1983. Methods Enzymol. 102, 185.
Tanaka, T., et al. 1983. Pharmacol. 26, 249.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.
Product Information
CAS number88519-57-7
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₄H₁₇ClN₂O₂S . HCl
Chemical formulaC₁₄H₁₇ClN₂O₂S . HCl
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetmlck
Primary Target IC<sub>50</sub>58 µM, 68 µM, against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase
Purity≥98% by HPLC and single spot by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
681636-1MG 04055977260168

Documentation

W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem Certificats d'analyse

TitreNuméro de lot
681636

Références bibliographiques

Aperçu de la référence bibliographique
Hidaka, H., and Tanaka, T. 1983. Methods Enzymol. 102, 185.
Tanaka, T., et al. 1983. Pharmacol. 26, 249.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-January-2010 RFH
SynonymsN-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide, HCl
DescriptionA cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 68 µM) and myosin light chain kinase (IC50 = 58 µM).
FormWhite solid
CAS number88519-57-7
Chemical formulaC₁₄H₁₇ClN₂O₂S . HCl
Structure formulaStructure formula
Purity≥98% by HPLC and single spot by TLC
SolubilityH₂O (35 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
Toxicity Standard Handling
ReferencesHidaka, H., and Tanaka, T. 1983. Methods Enzymol. 102, 185.
Tanaka, T., et al. 1983. Pharmacol. 26, 249.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.

Produits & Applications associés

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Référence Description
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Catégories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Phosphodiesterase Inhibitors
Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Myosin Light Chain Kinase (MLCK) Inhibitors