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662125 Ubiquitin Isopeptidase Inhibitor I, G5 - CAS 108477-18-5 - Calbiochem

The Ubiquitin Isopeptidase Inhibitor I, G5, also referenced under CAS 108477-18-5, controls the biological activity of Ubiquitin Isopeptidase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 3,5-bis((4-Nitrophenyl)methylene)-1,1-dioxide, tetrahydro-4H-thiopyran-4-one, NSC-144303

Primary Target: Ubiquitin isopeptidase activity
662125
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
108477-18-5C₁₉H₁₄N₂O₇S

Products

RéférenceConditionnement Qté
662125-10MG Ampoule plast. 10 mg
Description
OverviewA cell-permeable cross-conjugated α,β-unsaturated dienone compound that induces caspase activation and apoptosis (IC50 = 1.76 and 1.6 µM in E1A and E1A/C9DN cells, respectively) via the apoptosome-independent mitochondrial pathway by selectively inhibiting ubiquitin isopeptidase activity (IC50 = ~ 30 µM). The cellular expression of Bax and Bak is essential for G5-activated apoptosis, while Bcl-2 appears to protect cells against the effect of G5. G5 is more potent than, but otherwise exhibits similar pharmacological effects as, Ubiquitin Isopeptidase Inhibitor II, F6 (Cat. No. 662126). At higher concentrations (5-10 µM), shown to induce necrosis in apoptosis-resistant MEFs-DKO.
Catalogue Number662125
Brand Family Calbiochem®
Synonyms3,5-bis((4-Nitrophenyl)methylene)-1,1-dioxide, tetrahydro-4H-thiopyran-4-one, NSC-144303
References
ReferencesFontanini, A., et al. 2009. J. Biol. Chem. 284, 8369.
Aleo, E., et al. 2006. Cancer Res. 66, 9235.
Product Information
CAS number108477-18-5
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₉H₁₄N₂O₇S
Chemical formulaC₁₉H₁₄N₂O₇S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetUbiquitin isopeptidase activity
Primary Target IC<sub>50</sub>~ 30 µM against ubiquitin isopeptidase activity; 1.76 and 1.6 µM for the induction of caspase activation and apoptosis in E1A and E1A/C9DN cells, respectively
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsUnstable in DMSO; reconstitute just prior to use.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
662125-10MG 04055977261226

Documentation

Ubiquitin Isopeptidase Inhibitor I, G5 - CAS 108477-18-5 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Ubiquitin Isopeptidase Inhibitor I, G5 - CAS 108477-18-5 - Calbiochem Certificats d'analyse

TitreNuméro de lot
662125

Références bibliographiques

Aperçu de la référence bibliographique
Fontanini, A., et al. 2009. J. Biol. Chem. 284, 8369.
Aleo, E., et al. 2006. Cancer Res. 66, 9235.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-November-2023 JSW
Synonyms3,5-bis((4-Nitrophenyl)methylene)-1,1-dioxide, tetrahydro-4H-thiopyran-4-one, NSC-144303
DescriptionA cell-permeable cross-conjugated α,β-unsaturated dienone compound that induces caspase activation and apoptosis (IC50 = 1.76 and 1.6 µM in E1A and E1A/C9DN cells, respectively) via the apoptosome-independent mitochondrial pathway by selectively inhibiting ubiquitin isopeptidase activity (IC50 ~30 µM). The cellular expression of Bax and Bak is essential for G5-activated apoptosis, while Bcl-2 appears to protect cells against the effect of G5. G5 is more potent than, but otherwise exhibits similar pharmacological effects as, Ubiquitin Isopeptidase Inhibitor II, F6 (Cat. No. 662126). At higher concentrations (5-10 µM), shown to induce necrosis in apoptosis-resistant MEFs-DKO.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number108477-18-5
Chemical formulaC₁₉H₁₄N₂O₇S
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsUnstable in DMSO; reconstitute just prior to use.
Toxicity Irritant
ReferencesFontanini, A., et al. 2009. J. Biol. Chem. 284, 8369.
Aleo, E., et al. 2006. Cancer Res. 66, 9235.