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23-036M UbcH6 Protein, active, 250 µg

Active, full length, recombinant human UbcH6. N-terminal HA, 6His-tagged. For use in Enzyme Assays. Functions as an E2 enzyme in ubiquitination assays.

UbcH6 Protein, active, 250 µg : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Key Applications: Enzyme Assays
23-036M
250 µg  
Purchase on Sigma-Aldrich

Aperçu

Replacement Information

Tableau de caractéristiques principal

Key ApplicationsSpeciesCascade Component
Enzyme AssaysHuman E2
Description
Catalogue Number23-036M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionUbcH6 Protein, active, 250 µg
Alternate Names
  • Ubiquitin-conjugating enzyme E2 E1
  • Ubiquitin-protein ligase E1
  • UBE2E1
Background InformationUbiquitin-conjugating (E2) enzymes are characterized by the presence of a highly conserved ubiquitin-conjugating domain which accommodates ATP-activated ubiquitin (Ub) via a covalently linked thioester onto its active-site residue. E2 enzymes act via selective protein-protein interactions with the ubiquitin-activating E1 enzyme and ubiquitin ligase E3 enzymes and are able to differentiate effects on downstream substrates, either with a single Ub molecule or a Ub chain. While E3s are involved in substrate selection, E2s are the main determinants for selection of the lysine to construct Ub chains, which thereby directly control the cellular fate of the substrate.
UbcH6 has been shown to interact with a number of diverse E3 ligases, including RNF20/40, Trim32 and WWP2.
References
Product Information
Quality LevelMQ300
Applications
ApplicationActive, full length, recombinant human UbcH6. N-terminal HA, 6His-tagged. For use in Enzyme Assays. Functions as an E2 enzyme in ubiquitination assays.
Key Applications
  • Enzyme Assays
Biological Information
Cascade ComponentE2
Entrez Gene Number
Purification MethodPurified using immobilized metal affinity chromatography.
UniProt Number
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Packaging Information
Material Size250 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
23-036M 04053252294532

Produits & Applications associés

Alternative Packsize

Référence Description
23-036 UbcH6 Protein, active, 10 µg

Familles de produits

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Catégories

Life Science Research > Drug Discovery and Development > Ubiquitin and Proteasome Screening > Ubiquitin E2 Conjugating Enzymes
Life Science Research > Proteins and Enzymes > Ubiquitin E2 Conjugating Enzymes