662210 Sigma-AldrichUSP14 Inhibitor, IU1 - Calbiochem
The USP14 Inhibitor, IU1 controls the biological activity of USP14. This small molecule/inhibitor is primarily used for Cell Structure applications.
More>> The USP14 Inhibitor, IU1 controls the biological activity of USP14. This small molecule/inhibitor is primarily used for Cell Structure applications. Less<<Synonymes: 1-(1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(pyrrolidin-1-yl)ethanone, 1-(1-(4-Fluorophenyl)-2,5-dimethylpyrrol-3-yl)-2-pyrrolidin-1-ylethanone, Ubiquitin Specific Protease 14 Inhibitor, DUB Inhibitor IX
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Aperçu
Tableau de caractéristiques principal
Empirical Formula |
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C₁₈H₂₁FN₂O |
Products
Référence | Conditionnement | Qté | |
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662210-10MG | Flacon en verre | 10 mg |
Description | |
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Overview | A cell-permeable pyrrolylpyrrolidinyl-ethanone that inhibits the proteasome association-dependent USP14 deubiquitinase (DUB) activity in a reversible manner (IC50 = 4.7 µM against Ub-AMC hydrolysis), exhibiting little or no activity toward 8 other DUBs. Shown to downregulate tau, TDP-43, ATXN3, GFAP, and free Ub levels in MEF cultures in a dose- (25 to 100 µM), time-, and USP14-dependent manner. USP14-catalyzed trimming of protein surface polyubiquitin chains rescues proteasome-bound proteins from proteolytic degradation and thereby prevents the depletion of free ubiquitin pool in cells. Comparing to b-AP15 (Cat. No. 662140), IU1 does not inhibit UCH37/UCH-L5 (IC50 = 700 µM). |
Catalogue Number | 662210 |
Brand Family | Calbiochem® |
Synonyms | 1-(1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(pyrrolidin-1-yl)ethanone, 1-(1-(4-Fluorophenyl)-2,5-dimethylpyrrol-3-yl)-2-pyrrolidin-1-ylethanone, Ubiquitin Specific Protease 14 Inhibitor, DUB Inhibitor IX |
References | |
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References | Lee, B.H., et al. 2010. Nature 467, 179. |
Product Information | |
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Form | Beige solid |
Hill Formula | C₁₈H₂₁FN₂O |
Chemical formula | C₁₈H₂₁FN₂O |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Purity | ≥90% by HPLC |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Référence | GTIN |
662210-10MG | 04055977183894 |