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382425 Trequinsin, Hydrochloride - CAS 78416-81-6 - Calbiochem

Extremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC₅₀ = 300 pM) and platelet aggregation in vitro.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one, HCl, HL 725

Primary Target: cGMP-inhibited phosphodiesterase
382425
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
78416-81-6C₂₄H₂₇N₃O₃ · HCl

Products

RéférenceConditionnement Qté
382425-10MG Ampoule plast. 10 mg
Description
OverviewExtremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC50 = 300 pM) and platelet aggregation in vitro. Potentiates adenosine-stimulated cAMP accumulation.
Catalogue Number382425
Brand Family Calbiochem®
Synonyms9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one, HCl, HL 725
References
ReferencesSpina, D., et al. 1998. Life Sci. 62, 953.
Pillai, R., et al. 1994. J. Biol. Chem. 269, 30676.
Tang, K.M., et al. 1994. Eur. J. Pharmacol. 268, 105.
Whalin, M.E., et al. 1991. Mol. Pharmacol. 39, 711.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
DeClerck, F., et al. 1990. Blood Coag. Fibrinol. 1, 247.
Konkle, B.A., et al. 1990. J. Biol. Chem. 265, 21867.
Ruppert, D., and Weithmann, K.U. 1982. Life Sci. 31, 2037.
Product Information
CAS number78416-81-6
ATP CompetitiveN
FormPale yellow solid
Hill FormulaC₂₄H₂₇N₃O₃ · HCl
Chemical formulaC₂₄H₂₇N₃O₃ · HCl
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetcGMP-inhibited phosphodiesterase
Primary Target IC<sub>50</sub>300 pM against cGMP-inhibited phosphodiesterase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSUW7727000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +15°C to +30°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
382425-10MG 04055977190250

Documentation

Trequinsin, Hydrochloride - CAS 78416-81-6 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Trequinsin, Hydrochloride - CAS 78416-81-6 - Calbiochem Certificats d'analyse

TitreNuméro de lot
382425

Références bibliographiques

Aperçu de la référence bibliographique
Spina, D., et al. 1998. Life Sci. 62, 953.
Pillai, R., et al. 1994. J. Biol. Chem. 269, 30676.
Tang, K.M., et al. 1994. Eur. J. Pharmacol. 268, 105.
Whalin, M.E., et al. 1991. Mol. Pharmacol. 39, 711.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
DeClerck, F., et al. 1990. Blood Coag. Fibrinol. 1, 247.
Konkle, B.A., et al. 1990. J. Biol. Chem. 265, 21867.
Ruppert, D., and Weithmann, K.U. 1982. Life Sci. 31, 2037.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-July-2008 RFH
Synonyms9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one, HCl, HL 725
DescriptionExtremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC50 = 300 pM) and platelet aggregation in vitro. Potentiates adenosine-stimulated cAMP accumulation.
FormPale yellow solid
CAS number78416-81-6
RTECSUW7727000
Chemical formulaC₂₄H₂₇N₃O₃ · HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (500 µM)
Storage Protect from moisture
+15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesSpina, D., et al. 1998. Life Sci. 62, 953.
Pillai, R., et al. 1994. J. Biol. Chem. 269, 30676.
Tang, K.M., et al. 1994. Eur. J. Pharmacol. 268, 105.
Whalin, M.E., et al. 1991. Mol. Pharmacol. 39, 711.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
DeClerck, F., et al. 1990. Blood Coag. Fibrinol. 1, 247.
Konkle, B.A., et al. 1990. J. Biol. Chem. 265, 21867.
Ruppert, D., and Weithmann, K.U. 1982. Life Sci. 31, 2037.