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580566 Tenovin-1 - CAS 380315-80-0 - Calbiochem

A cell-permeable benzoylthiourea compound that acts as a reversible inhibitor of class III HDAC sirtuins against SirT2 (IC₅₀ = ~ 10 µM).

Tenovin-1 - CAS 380315-80-0 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N-(4-tert-Butylbenzoyl)-Nʹ-(4-acetylaminophenyl)-thiourea, SIRT2 Inhibitor V

580566
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
380315-80-0C₂₀H₂₃N₃O₂S

Products

RéférenceConditionnement Qté
580566-10MG Ampoule plast. 10 mg
Description
OverviewA cell-permeable benzoylthiourea compound that acts as a reversible inhibitor of class III HDAC sirtuins against SirT2 (IC50 = ~ 10 µM). Based on studies using the more soluble analog Tenovin-6, Tenovin-1 is expected not to compete with substrate binding and display lower potency against SirT1/3 (IC50 = 21/67 µM using Tenovin-6). Tenovin-1 (10 µM) up-regulates cellular p53 protein, but not mRNA, level in MCF-7 (≥6-fold in 6 h), presumably by blocking mdm2-mediated p53 degradation. Two day Tenovin-1 treatment (10 µM) results in selective killing of cancer cells with functional p53, but not p53-lacking cancer cells or normal human dermal fibroblasts. Despite its low aqueous solubility, administration of Tenovin-1 suspension is shown to effectively reduce BL2 and ARN8 xenographs in mice in vivo (≥50% reduction with 92 mg/kg, daily, i.p.).
Catalogue Number580566
Brand Family Calbiochem®
SynonymsN-(4-tert-Butylbenzoyl)-Nʹ-(4-acetylaminophenyl)-thiourea, SIRT2 Inhibitor V
References
ReferencesLain, S., et al. 2008. Cancer Cell 13, 454.
Product Information
CAS number380315-80-0
FormWhite solid
Hill FormulaC₂₀H₂₃N₃O₂S
Chemical formulaC₂₀H₂₃N₃O₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25-36-45

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
580566-10MG 04055977265583

Documentation

Tenovin-1 - CAS 380315-80-0 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Tenovin-1 - CAS 380315-80-0 - Calbiochem Certificats d'analyse

TitreNuméro de lot
580566

Références bibliographiques

Aperçu de la référence bibliographique
Lain, S., et al. 2008. Cancer Cell 13, 454.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
SynonymsN-(4-tert-Butylbenzoyl)-Nʹ-(4-acetylaminophenyl)-thiourea, SIRT2 Inhibitor V
DescriptionA cell-permeable benzoylthiourea compound that acts as a reversible inhibitor of class III HDAC sirtuins (IC50 against SirT2 ~10 µM). Based on studies using the more soluble analog Tenovin-6, Tenovin-1 is expected not to compete with substrate binding and display lower potency against SirT1/3 (IC50 = 21/67 µM using Tenovin-6). Tenovin-1 (10 µM) up-regulates cellular p53 protein, but not mRNA, level in MCF-7 (≥6-fold in 6 h), presumably by blocking mdm2-mediated p53 degradation. Two day Tenovin-1 treatment (10 µM) results in selective killing of cancer cells with functional p53, but not p53-lacking cancer cells or normal human dermal fibroblasts. Despite its low aqueous solubility, administration of Tenovin-1 suspension is shown to effectively reduce BL2 and ARN8 xenographs in mice in vivo (≥50% reduction with 92 mg/kg daily i.p.).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number380315-80-0
Chemical formulaC₂₀H₂₃N₃O₂S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLain, S., et al. 2008. Cancer Cell 13, 454.