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533574 TRPML3 Activator, ML123 - CAS 384352-24-3 - Calbiochem

A highly selective agonist of TRPML3 channel (EC₅₀ = 873 nM)

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: SF-21, CID2911646, ML123, ML 123, 4-Chloro-N-(2-morpholinocyclohexyl)benzenesulfonamide, Transient Receptor Potential Channel 3 Activator, SID24801657, Racemate, SR-1984

Primary Target: TRPML3
533574
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
384352-24-3C₁₆H₂₃ClN₂O₃S

Products

RéférenceConditionnement Qté
5335740001 Flacon en verre 25 mg
Description
OverviewA non-cytotoxic morpholinyl-cyclohexylbenzenesulfonamide compound that acts as a selective agonist of TRPML3 channel (EC50 = 873 nM in hTRPML3-YPF transfected HEK293 cells). Displays significantly weaker agonistic activity for TRPML2 channel (54.5% at 10 µM) and is shown to be inactive against hTRPML1, hTRPM2, mTRPV2, hTRPC3, drTRPN1, and hTRPA1 (~10 µM). Also binds to sigma-1 receptor at much higher concentrations (IC50 = 31 µM).
Catalogue Number533574
Brand Family Calbiochem®
SynonymsSF-21, CID2911646, ML123, ML 123, 4-Chloro-N-(2-morpholinocyclohexyl)benzenesulfonamide, Transient Receptor Potential Channel 3 Activator, SID24801657, Racemate, SR-1984
References
ReferencesAntolin, A.A., and Mestres, J. 2015. ACS Chem. Biol. 10, 395.
Grimm, C., et al. 2012. J. Biol. Chem. 287, 22701.
Saldanha, S., et al. 2010. Probe Reports from the NIH Molecular Libraries Program.
Grimm, C., et al. 2010. Chem. Biol. 17, 135.
Product Information
CAS number384352-24-3
FormOff-white solid
Hill FormulaC₁₆H₂₃ClN₂O₃S
Chemical formulaC₁₆H₂₃ClN₂O₃S
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetTRPML3
Purity≥92% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
5335740001 04055977287011

Documentation

TRPML3 Activator, ML123 - CAS 384352-24-3 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Références bibliographiques

Aperçu de la référence bibliographique
Antolin, A.A., and Mestres, J. 2015. ACS Chem. Biol. 10, 395.
Grimm, C., et al. 2012. J. Biol. Chem. 287, 22701.
Saldanha, S., et al. 2010. Probe Reports from the NIH Molecular Libraries Program.
Grimm, C., et al. 2010. Chem. Biol. 17, 135.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-July-2016 JSW
SynonymsSF-21, CID2911646, ML123, ML 123, 4-Chloro-N-(2-morpholinocyclohexyl)benzenesulfonamide, Transient Receptor Potential Channel 3 Activator, SID24801657, Racemate, SR-1984
DescriptionA non-cytotoxic morpholinyl-cyclohexylbenzenesulfonamide compound that acts as a selective agonist of TRPML3 channel (EC50 = 873 nM in hTRPML3-YPF transfected HEK293 cells). Displays significantly weaker agonistic activity for TRPML2 channel (54.5% at 10 µM) and is shown to be inactive against hTRPML1, hTRPM2, mTRPV2, hTRPC3, drTRPN1, and hTRPA1 (~10 µM). Also binds to sigma-1 receptor at much higher concentrations (IC50 = 31 µM).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number384352-24-3
Chemical formulaC₁₆H₂₃ClN₂O₃S
Purity≥92% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesAntolin, A.A., and Mestres, J. 2015. ACS Chem. Biol. 10, 395.
Grimm, C., et al. 2012. J. Biol. Chem. 287, 22701.
Saldanha, S., et al. 2010. Probe Reports from the NIH Molecular Libraries Program.
Grimm, C., et al. 2010. Chem. Biol. 17, 135.