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534359 TRPM3 Agonist, CIM0216 - CAS 1031496-06-6 - Calbiochem

Highly efficacious TRPM3 Agonist that opens both the central Ca2+-conducting pore and the alternative cation permeation pathway. Causes nocifensive behavior in mice.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: ±-2-(3,4-Dihydroquinolin-1(2H)-yl)-N-(5-methylisoxazol-3-yl)-2-phenylacetamide, Transient Receptor Potential Cation Channel subfamily M member 3 Agonist, CIM-0216

Primary Target: TRPM3
534359
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
1031496-06-6C₂₁H₂₁N₃O₂

Products

RéférenceConditionnement Qté
5343590001 Flacon en verre 25 mg
Description
OverviewA cell-permeable isoxazolyl-phenylacetamide based compound that acts as a potent, reversible, temperature-dependent and selective activator of both human and murine TRPM3 currents (EC50 = 770 nM for elevating [Ca2+]i levels in HEK293-TRPM3 cells; maximal activation within ~100 s) in a dose-dependent & membrane-delimited manner. Poorly activates human TRPM1, TRPM2, TRPM4, TRPM5, TRPM6, TRPM7, TRPM8 and TRPV1. At higher concentrations, blocks hTRPM2, hTRPM5 & hTRPM8 (by 17%, 34% & 61%, respectively, at 10 µM). Elicits the opening of both the central calcium-conducting pore and the alternative cation permeation pathway. Causes nocifensive behavior in mice (2.5 nmol, intradermal), induces pain, and stimulates the release of CGRP from skin nerve terminals and insulin from pancreatic islets. Shown to display greater efficacy than the canonical TRPM3 agonist, pregnenolone sulfate.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number534359
Brand Family Calbiochem®
Synonyms±-2-(3,4-Dihydroquinolin-1(2H)-yl)-N-(5-methylisoxazol-3-yl)-2-phenylacetamide, Transient Receptor Potential Cation Channel subfamily M member 3 Agonist, CIM-0216
DescriptionTRPM3 Agonist, CIM0216
References
ReferencesHeld, K., et al. 2015. Proc. Natl. Acad. Sci. USA. 112, E1363.
Product Information
CAS number1031496-06-6
FormWhite to light yellow solid
Hill FormulaC₂₁H₂₁N₃O₂
Chemical formulaC₂₁H₂₁N₃O₂
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetTRPM3
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
5343590001 04054839059247

Documentation

TRPM3 Agonist, CIM0216 - CAS 1031496-06-6 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

TRPM3 Agonist, CIM0216 - CAS 1031496-06-6 - Calbiochem Certificats d'analyse

TitreNuméro de lot
534359

Références bibliographiques

Aperçu de la référence bibliographique
Held, K., et al. 2015. Proc. Natl. Acad. Sci. USA. 112, E1363.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-October-2024 JSW
Synonyms±-2-(3,4-Dihydroquinolin-1(2H)-yl)-N-(5-methylisoxazol-3-yl)-2-phenylacetamide, Transient Receptor Potential Cation Channel subfamily M member 3 Agonist, CIM-0216
DescriptionA cell-permeable isoxazolyl-phenylacetamide based compound that acts as a potent, reversible, temperature-dependent and selective activator of both human and murine TRPM3 currents (EC50 = 770 nM for elevating [Ca2+]i levels in HEK293-TRPM3 cells; maximal activation within ~100 s) in a dose-dependent & membrane-delimited manner. Poorly activates human TRPM1, TRPM2, TRPM4, TRPM5, TRPM6, TRPM7, TRPM8 and TRPV1. At higher concentrations, blocks hTRPM2, hTRPM5 & hTRPM8 (by 17%, 34% & 61%, respectively, at 10 µM). Elicits the opening of both the central calcium-conducting pore and the alternative cation permeation pathway. Causes nocifensive behavior in mice (2.5 nmol, intradermal), induces pain, and stimulates the release of CGRP from skin nerve terminals and insulin from pancreatic islets. Shown to display greater efficacy than the canonical TRPM3 agonist, pregnenolone sulfate.
FormWhite to light yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1031496-06-6
Chemical formulaC₂₁H₂₁N₃O₂
Purity≥97% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHeld, K., et al. 2015. Proc. Natl. Acad. Sci. USA. 112, E1363.