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579051 TAPI-1 - CAS 171235-71-5 - Calbiochem

TAPI-1, CAS 171235-71-5, is a structural analog of TAPI-0 with similar in vitro efficacy for the inhibition of MMPs and TACE. Blocks the shedding of several cell surface proteins.

TAPI-1 - CAS 171235-71-5 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine, 2-aminoethyl Amide, TNF-α Protease Inhibitor-1

Primary Target: MMPs and TACE
579051
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Aperçu

Tableau de caractéristiques principal

CAS #Empirical Formula
171235-71-5C₂₆H₃₇N₅O₅

Products

RéférenceConditionnement Qté
579051-1MG Ampoule plast. 1 mg
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Description
OverviewA structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE (TNF-α converting enzyme/ADAM17). TAPI-1 also blocks the shedding of several cell surface proteins such as IL-6 receptor, p60 TNF receptor, and p80 TNF receptor. Blocks constitutive (IC50 = 8.09 µM) and muscarinic receptor-stimulated (IC50 = 3.61 µM) sAAPα release in HEK 293 cells expressing M3 muscarinic receptors. A 10 mM (500 µg/100 µl) solution of TAPI-1 (Cat. No. 579050) in DMSO is also available.
Catalogue Number579051
Brand Family Calbiochem®
SynonymsN-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine, 2-aminoethyl Amide, TNF-α Protease Inhibitor-1
References
ReferencesSlack, B.E., et al. 2001. Biochem. J. 357, 787.
Vincent, B., et al. 2001. J. Biol. Chem. 276, 37743.
Hooper, N.M., et al. 1997. Biochem. J. 321, 265.
Crowe, P.D., et al. 1995. J. Exp. Med. 181, 1205.
Mullberg, J., et al. 1995. J. Immunol. 155, 5198.
Mohler, K.M., et al. 1994. Nature 370, 218.
Product Information
CAS number171235-71-5
ATP CompetitiveN
DeclarationManufactured exclusively by Peptides International, Louisville, Kentucky, USA.
FormWhite solid
Hill FormulaC₂₆H₃₇N₅O₅
Chemical formulaC₂₆H₃₇N₅O₅
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetMMPs and TACE
Primary Target IC<sub>50</sub>8.09 µM and 3.61 µM blocking constitutive and muscarinic receptor-stimulated sAAPα release in HEK 293 cells expressing M3 muscarinic receptors, respectively
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Référence GTIN
579051-1MG 04055977265361