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574102 Sulindac Sulfide - CAS 32004-67-4 - Calbiochem

A cell-permeable, active metabolite of Sulindac.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid

Primary Target: COX-1
574102
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
32004-67-4C₂₀H₁₇FO₂S

Products

RéférenceConditionnement Qté
574102-5MG Ampoule plast. 5 mg
Description
OverviewA cell-permeable, active metabolite of Sulindac (Cat. No. 574100). Strongly inhibits Ras-induced malignant transformation and Ras/Raf-dependent transactivation. Also decreases the Ras-induced activation of c-Raf-1 kinase. Inhibits growth and induces apoptosis in prostate cancer cell lines. Selectively inhibits COX-1 (ID50 = 500 nM) compared to prostaglandin H synthase-2 (PGHS-2; COX-2; ID50 = 14 µM). Preferentially inhibits the secretion of Aβ42 in CHO cells stably transfected with both APP75, and the PS1 mutant M146L.
Catalogue Number574102
Brand Family Calbiochem®
Synonyms(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid
References
ReferencesWeggen, S., et al. 2001. Nature 414, 212.
Lim, J.T., et al. 1999. Biochem. Pharmacol. 58, 1097.
Herrmann, C., et al. 1998. Oncogene 17, 1769.
Picariello, L., et al. 1998. Eur. J. Pharmacol. 360, 105.
Arber, N., et al. 1997. Gastroenterology 113, 1892.
Meade, E.A., et al. 1993. J. Biol. Chem. 268, 6610.
Product Information
CAS number32004-67-4
ATP CompetitiveN
FormYellow-orange solid
Hill FormulaC₂₀H₁₇FO₂S
Chemical formulaC₂₀H₁₇FO₂S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCOX-1
Primary Target IC<sub>50</sub>ID50 = 500 nM against COX-1
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 22-42/43-63

Harmful if swallowed.
May cause sensitization by inhalation and skin contact.
Possible risk of harm to the unborn child.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +15°C to +30°C
Do not freeze Ok to freeze
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
574102-5MG 04055977189551

Documentation

Sulindac Sulfide - CAS 32004-67-4 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Sulindac Sulfide - CAS 32004-67-4 - Calbiochem Certificats d'analyse

TitreNuméro de lot
574102

Références bibliographiques

Aperçu de la référence bibliographique
Weggen, S., et al. 2001. Nature 414, 212.
Lim, J.T., et al. 1999. Biochem. Pharmacol. 58, 1097.
Herrmann, C., et al. 1998. Oncogene 17, 1769.
Picariello, L., et al. 1998. Eur. J. Pharmacol. 360, 105.
Arber, N., et al. 1997. Gastroenterology 113, 1892.
Meade, E.A., et al. 1993. J. Biol. Chem. 268, 6610.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-September-2008 RFH
Synonyms(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid
DescriptionAn active metabolite of the non-steroidal anti-inflammatory drug Sulindac (Cat. No. 574100). Inhibits Ras signaling. Strongly inhibits Ras-induced malignant transformation and Ras/Raf-dependent transactivation. Also decreases the Ras-induced activation of c-Raf-1 kinase. Inhibits cell growth and induces apoptosis in a time-and dose-dependent manner. Selectively inhibits prostaglandin H synthase-1 (PGHS-1; COX-1; ID50 = 0.5 µM) relative to prostaglandin H synthase-2 (PGHS-2; COX-2; ID50 = 14 µM). Reduces Aβ42 production independently of COX inhibition.
FormYellow-orange solid
CAS number32004-67-4
Chemical formulaC₂₀H₁₇FO₂S
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (25 mg/ml) or ethanol (5 mg/ml)
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Toxicity Harmful & Carcinogenic / Teratogenic
ReferencesWeggen, S., et al. 2001. Nature 414, 212.
Lim, J.T., et al. 1999. Biochem. Pharmacol. 58, 1097.
Herrmann, C., et al. 1998. Oncogene 17, 1769.
Picariello, L., et al. 1998. Eur. J. Pharmacol. 360, 105.
Arber, N., et al. 1997. Gastroenterology 113, 1892.
Meade, E.A., et al. 1993. J. Biol. Chem. 268, 6610.