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14-326 Src Protein, active, 10 µg

Active, N-Terminal His6-tagged, recombinant, full-length, human Src. For use in Kinase Assays.

Src Protein, active, 10 µg : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
14-326
10 µg  2 vials at 5μg each
Also available in 250μg size (2x125μg)--call for pricing and availability and reference catalog number 14-326M when ordering the 250μg size.
Purchase on Sigma-Aldrich

Aperçu

Replacement Information
Description
Catalogue Number14-326
Brand Family Upstate
Trade Name
  • Upstate
DescriptionSrc Protein, active, 10 µg
OverviewN-Terminal His6-tagged, recombinant, full-length, human Src.
References
Product Information
Quality LevelMQ100
Applications
ApplicationActive, N-Terminal His6-tagged, recombinant, full-length, human Src. For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
SourceHuman c-src, expressed in Sf21 cells.
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene SummaryThis gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
Gene Symbol
  • SRC
  • ASV
  • c-src
  • p60-Src
  • SRC1
  • c-SRC
  • pp60c-src
Protein TargetSrc
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyTK
UniProt Number
UniProt SummarySIZE: 536 amino acids; 59835 Da
SUBUNIT: Interacts with DDEF1/ASAP1 via its SH3 domain. Interacts with CCPG1 (By similarity). Interacts with CDCP1, PELP1, TGFB1I1 and TOM1L2.
PTM: Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. The phosphorylated tail interacts with the SH2 domain thereby repressing kinase activity.
SIMILARITY: SwissProt: P12931 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
Molecular Weight61.7kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by phosphorylation of Src Substrate Peptide
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions1 year at -70°C
Packaging Information
Material Size10 µg
Material Package2 vials at 5μg each
Also available in 250μg size (2x125μg)--call for pricing and availability and reference catalog number 14-326M when ordering the 250μg size.
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
14-326 04053252618802

Documentation

Src Protein, active, 10 µg FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Src Protein, active, 10 µg Certificats d'analyse

TitreNuméro de lot
Src, active (Recombinant enzyme expressed in Sf21 insect cells) - 2070985-B 2070985-B
Src, active - 2070985-A 2070985-A
Src, active - 2070985-C 2070985-C
Src, active - 2070985-D 2070985-D
Src, active - 2070985-E 2070985-E
Src, active - 2070985-F 2070985-F
Src, active - 2070985-G 2070985-G
Src, active - D8CN006U-V D8CN006U-V

Références bibliographiques

Aperçu de la référence bibliographiqueNº PubMed
Protein tyrosine kinases, with emphasis on the Src family.
Courtneidge, S A
Semin. Cancer Biol., 5: 239-46 (1994)  1993

Afficher le résumé 		7528561 7528561

Produits & Applications associés

Alternative Packsize

Référence Description
14-326M Src Protein, active, 250 µg

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Catégories

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases