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509106 Sphingosine Kinase-2 Inhibitor, K145 - CAS 1309444-75-4 - Calbiochem

A cell permeable, selective, sphingosine competitive inhibitor of spingosine Kinase -2 (IC₅₀ = 4.3 µM).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: SphK2 Inhibitor, K145

Primary Target: Sphk2
509106
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
1309444-75-4C₁₈H₂₄N₂O₃S

Products

RéférenceConditionnement Qté
5091060001 Flacon en verre 10 mg
Description
OverviewA cell permeable, orally bioavailable thiazolidine-2,4-dione derivative that acts as a selective, sphingosine competitive inhibitor of spingosine Kinase -2 (SphK2; IC50 = 4.3 µM; Ki = 6.4 µM), but does not affect the activities of sphingosine kinase-1, ceremide kinase, and ceramide synthase even at high concentration (~10 micro;M). Shown to inhibit the growth of U937 human leukemic monocyte lymphoma cells by inducing apoptosis and inhibiting the phosphorylation of ERK and Akt. Blocks the growth of U937 cells in nude mice and inhibits the growth of JC tumor cells in BALB/c mice without any apparent toxicity.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number509106
Brand Family Calbiochem®
SynonymsSphK2 Inhibitor, K145
References
ReferencesLiu, K., et al. 2013. PLos One 8, e56471.
Product Information
CAS number1309444-75-4
FormOff-white powder
Hill FormulaC₁₈H₂₄N₂O₃S
Chemical formulaC₁₈H₂₄N₂O₃S
Quality LevelMQ100
Applications
Biological Information
Primary TargetSphk2
Primary Target IC<sub>50</sub>4.3 µ
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
5091060001 04055977261493

Documentation

Sphingosine Kinase-2 Inhibitor, K145 - CAS 1309444-75-4 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Références bibliographiques

Aperçu de la référence bibliographique
Liu, K., et al. 2013. PLos One 8, e56471.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-April-2014 JSW
SynonymsSphK2 Inhibitor, K145
DescriptionA cell permeable, orally bioavailable thiazolidine-2,4-dione derivative that acts as a selective, sphingosine competitive inhibitor of spingosine Kinase -2 (SphK2; IC50 = 4.3 µM; Ki = 6.4 µM), but does not affect the activities of sphingosine kinase-1, ceremide kinase, and ceramide synthase even at high concentration (~10 micro;M). Shown to inhibit the growth of U937 human leukemic monocyte lymphoma cells by inducing apoptosis and inhibiting the phosphorylation of ERK and Akt. Blocks the growth of U937 cells in nude mice and inhibits the growth of JC tumor cells in BALB/c mice without any apparent toxicity.
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number1309444-75-4
Chemical formulaC₁₈H₂₄N₂O₃S
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml) or H₂O (2.5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity Standard Handling
ReferencesLiu, K., et al. 2013. PLos One 8, e56471.