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567732 Sphingosine Kinase 1 Inhibitor, SKI-178 - Calbiochem

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Nʹ-(1E)-1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide, Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide

567732
Purchase on Sigma-Aldrich

Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₂₁H₂₂N₄O₄

Products

RéférenceConditionnement Qté
567732-10MG Flacon en verre 10 mg
Description
OverviewA cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (Ki = 1.33 and >> 25 µM, respectively). Shown to suppress sphingosine-1-phosphate (S1P) production in A549 cells and efficiently induce apoptosis in several tumor cells (IC50 in the range of 0.1-1.8 µM).
Catalogue Number567732
Brand Family Calbiochem®
SynonymsNʹ-(1E)-1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide, Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide
References
ReferencesHengst, J.A., et al. 2010. .Bioorg. Med. Chem. Lett. 20, 7498
Product Information
FormOff-white powder
Hill FormulaC₂₁H₂₂N₄O₄
Chemical formulaC₂₁H₂₂N₄O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥92% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
567732-10MG 04055977190861

Documentation

Sphingosine Kinase 1 Inhibitor, SKI-178 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Sphingosine Kinase 1 Inhibitor, SKI-178 - Calbiochem Certificats d'analyse

TitreNuméro de lot
567732

Références bibliographiques

Aperçu de la référence bibliographique
Hengst, J.A., et al. 2010. .Bioorg. Med. Chem. Lett. 20, 7498
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-February-2013 JSW
SynonymsNʹ-(1E)-1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide, Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide
DescriptionA cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (Ki = 1.33 and >> 25 µM, respectively). Shown to suppress sphingosine-1-phosphate (S1P) production in A549 cells and efficiently induce apoptosis in several tumor cells (IC50 in the range of 0.1-1.8 µM).
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₁H₂₂N₄O₄
Structure formulaStructure formula
Purity≥92% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHengst, J.A., et al. 2010. .Bioorg. Med. Chem. Lett. 20, 7498