Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

567375 Smac-N7 Peptide, Cell-Permeable - Calbiochem

The Smac-N7 peptide is modified to be cell permeant by linking the lysine carboxyl terminal to the arginine of Antennapedia homeodomain 16-mer peptide via a proline linker.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: AVPIAQKPRQIKIWFQNRRMKWKK

Primary Target: Promotes procaspase-3 activation
567375
Purchase on Sigma-Aldrich

Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₁₄₂H₂₃₂N₄₄O₂₉S

Products

RéférenceConditionnement Qté
567375-1MG Ampoule plast. 1 mg
Description
OverviewThe Smac-N7 peptide (Cat. No. 567370) is modified to be cell permeant by linking the lysine carboxyl terminal to the arginine of Antennapedia homeodomain 16-mer peptide via a proline linker.
Catalogue Number567375
Brand Family Calbiochem®
SynonymsAVPIAQKPRQIKIWFQNRRMKWKK
References
ReferencesSrinivasula, S.M., et al. 2001. Nature 410, 112.
Chai, J., et al. 2000. Nature 406, 855.
Liu, Z., et al. 2000. Nature 408, 1004.
Srinivasula, S.M., et al. 2000. J. Biol. Chem. 275, 36152.
Product Information
ATP CompetitiveN
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₄₂H₂₃₂N₄₄O₂₉S
Chemical formulaC₁₄₂H₂₃₂N₄₄O₂₉S
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetPromotes procaspase-3 activation
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceH-Ala-Val-Pro-Ile-Ala-Gln-Lys-Pro-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
567375-1MG 07790788051594

Documentation

Smac-N7 Peptide, Cell-Permeable - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Smac-N7 Peptide, Cell-Permeable - Calbiochem Certificats d'analyse

TitreNuméro de lot
567375

Références bibliographiques

Aperçu de la référence bibliographique
Srinivasula, S.M., et al. 2001. Nature 410, 112.
Chai, J., et al. 2000. Nature 406, 855.
Liu, Z., et al. 2000. Nature 408, 1004.
Srinivasula, S.M., et al. 2000. J. Biol. Chem. 275, 36152.

Brochure

Titre
Caspases and other Apoptosis Related Tools Brochure
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-September-2008 RFH
SynonymsAVPIAQKPRQIKIWFQNRRMKWKK
DescriptionThe Smac-N7 peptide (Cat. No. 567370) where the lysine carboxy terminal is linked to the arginine of Antennapedia homeodomain 16-mer peptide (underlined) via a proline linker to make it cell-permeable. Smac-N7 peptide contains the N-terminal seven residues of Smac and promotes the activation of procaspase-3 (~10 µM). Also, promotes the catalytic activity of caspase-9 in the presence of XIAP.
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₄₂H₂₃₂N₄₄O₂₉S
Peptide SequenceH-Ala-Val-Pro-Ile-Ala-Gln-Lys-Pro-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesSrinivasula, S.M., et al. 2001. Nature 410, 112.
Chai, J., et al. 2000. Nature 406, 855.
Liu, Z., et al. 2000. Nature 408, 1004.
Srinivasula, S.M., et al. 2000. J. Biol. Chem. 275, 36152.