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572650 SU9516 - CAS 666837-93-0 - Calbiochem

A cell-permeable 3-substituted indolinone compound that displays anti-proliferative and proapoptotic properties in tumor cells.

SU9516 - CAS 666837-93-0 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one

Primary Target: Cdk2/A
572650
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
666837-93-0C₁₃H₁₁N₃O₂

Products

RéférenceConditionnement Qté
572650-5MG Ampoule plast. 5 mg
Description
OverviewA cell-permeable 3-substituted indolinone compound that displays anti-proliferative and proapoptotic properties in tumor cells. Acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks; IC50 = 22 nM for Cdk2/A; 40 nM for Cdk1/B; 200 nM for Cdk4/D1). It shows no significant effect (IC50 >10 µM) on the activities of PKC, p38, PDGFRβ, or EGFR. Inhibits the proliferation of growth factor-stimulated colon carcinoma cells by binding to Cdk2 and preventing the phosphorylation of pRb and its dissociation from E2F.
Catalogue Number572650
Brand Family Calbiochem®
Synonyms3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one
References
ReferencesYu, B., et al. 2002. Biochem. Pharmacol. 64, 1091.
Lane, M.E., et al. 2001. Cancer Res. 61, 6170.
Product Information
CAS number666837-93-0
ATP CompetitiveY
FormYellow to orange solid
Hill FormulaC₁₃H₁₁N₃O₂
Chemical formulaC₁₃H₁₁N₃O₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCdk2/A
Primary Target IC<sub>50</sub>22 nM for Cdk2/A; 40 nM for Cdk1/B; 200 nM for Cdk4/D1
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
572650-5MG 04055977266313

Documentation

SU9516 - CAS 666837-93-0 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

SU9516 - CAS 666837-93-0 - Calbiochem Certificats d'analyse

TitreNuméro de lot
572650

Références bibliographiques

Aperçu de la référence bibliographique
Yu, B., et al. 2002. Biochem. Pharmacol. 64, 1091.
Lane, M.E., et al. 2001. Cancer Res. 61, 6170.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-December-2018 JSW
Synonyms3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one
DescriptionA cell-permeable, 3-substituted indolinone compound that displays anti-proliferative and pro-apoptotic properties in tumor cells. Acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks) (IC50 = 22 nM for Cdk2/A; 40 nM for Cdk1/B; 200 nM for Cdk4/D1). Exhibits no significant effect on the activities of PKC, p38, PDGFRβ, or EGFR (IC50 >10 µM). Reported to inhibit the proliferation of growth factor-stimulated colon carcinoma cells by binding to Cdk2 and preventing the phosphorylation of pRb and its dissociation from E2F.
FormYellow to orange solid
CAS number666837-93-0
Chemical formulaC₁₃H₁₁N₃O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesYu, B., et al. 2002. Biochem. Pharmacol. 64, 1091.
Lane, M.E., et al. 2001. Cancer Res. 61, 6170.