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573132 STAT3 Inhibitor XVIII, BP-1-102 - Calbiochem

STAT3 Inhibitor XVIII, BP-1-102, CAS 1334493-07-0, binds to the three subpockets of STAT3 SH2 domain and blocks STAT3 phosphorylation, dimerization, and DNA-binding activity.

STAT3 Inhibitor XVIII, BP-1-102 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid

Primary Target: Stat3
573132
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
1334493-07-0C₂₉H₂₇F₅N₂O₆S

Products

RéférenceConditionnement Qté
573132-10MG Flacon en verre 10 mg
Description
OverviewA cell-permeable, orally bioavailable amidosalicylic acid compound that selectively binds the three subpockets of Stat3 SH2 domain surface (KD = 504 nM) and blocks Stat3 phosphorylation, dimerization, and DNA-binding activity in a dose-dependent manner. Preferentially disrupts the high affinity binding between Stat3 and IL-6R/gp130-derived pTyr904 peptide (IC50 = 4.1 µM). Does not exert any significant effect on the phosphorylation status of Shc, Src, JAK1/2, Erk1/2, or Akt. Shown to reduce Stat3-dependent growth, survival, migration, and invasion of tumor cells in vitro and suppress the growth of aberrant Stat3-harboring human breast and lung tumor xenografts (3 mg/kg, i,v. or o.g.) in vivo.
Catalogue Number573132
Brand Family Calbiochem®
Synonyms4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid
References
ReferencesZhang, X., et al. Proc. Natl. Acad. Sci. USA 109, 9623.
Product Information
CAS number1334493-07-0
FormWhite powder
Hill FormulaC₂₉H₂₇F₅N₂O₆S
Chemical formulaC₂₉H₂₇F₅N₂O₆S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationSTAT3 Inhibitor XVIII, BP-1-102, CAS 1334493-07-0, binds to the three subpockets of STAT3 SH2 domain and blocks STAT3 phosphorylation, dimerization, and DNA-binding activity.
Biological Information
Primary TargetStat3
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
573132-10MG 04055977189513

Documentation

STAT3 Inhibitor XVIII, BP-1-102 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

STAT3 Inhibitor XVIII, BP-1-102 - Calbiochem Certificats d'analyse

TitreNuméro de lot
573132

Références bibliographiques

Aperçu de la référence bibliographique
Zhang, X., et al. Proc. Natl. Acad. Sci. USA 109, 9623.

Informations techniques

Titre
JAK/STAT Signaling Research Focus
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-January-2013 JSW
Synonyms4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid
DescriptionA cell-permeable, orally bioavailable amidosalicylic acid compound that selectively binds the three subpockets of Stat3 SH2 domain surface (KD = 504 nM) and blocks Stat3 phosphorylation, dimerization, and DNA-binding activity in a dose-dependent manner. Preferentially disrupts the high affinity binding between Stat3 and IL-6R/gp130-derived pTyr904 peptide (IC50 = 4.1 µM). Does not exert any significant effect on the phosphorylation status of Shc, Src, JAK1/2, Erk1/2, or Akt. Shown to reduce Stat3-dependent growth, survival, migration, and invasion of tumor cells in vitro and suppress the growth of aberrant Stat3-harboring human breast and lung tumor xenografts (3 mg/kg, i,v. or o.g.) in vivo.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
CAS number1334493-07-0
Chemical formulaC₂₉H₂₇F₅N₂O₆S
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesZhang, X., et al. Proc. Natl. Acad. Sci. USA 109, 9623.