566330 Sigma-AldrichSIRT1/2 Inhibitor VIII, Salermide - CAS 1105698-15-4 - Calbiochem
The SIRT1/2 Inhibitor VIII, Salermide, also referenced under CAS 1105698-15-4, controls the biological activity of SIRT1/2. This small molecule/inhibitor is primarily used for Cell Structure applications.
More>> The SIRT1/2 Inhibitor VIII, Salermide, also referenced under CAS 1105698-15-4, controls the biological activity of SIRT1/2. This small molecule/inhibitor is primarily used for Cell Structure applications. Less<<FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: N-(3-((2-Hydroxynaphthalen-1-ylmethylene)-amino)-phenyl)-2-phenyl-propionamide, SIRT1 Inhibitor VI, SIRT2 Inhibitor VIII
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Aperçu
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Tableau de caractéristiques principal
| CAS # | Empirical Formula |
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| 1105698-15-4 | C₂₆H₂₂N₂O₂ |
Products
| Référence | Conditionnement | Qté | |
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| 566330-10MG | Ampoule plast. | 10 mg |
| Description | |
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| Overview | A cell-permeable 2-hydroxy-naphthaldehyde that acts as an inhibitor against sirtuins SirT1 and SirT2, members of class III HDACs. Salermide effectively inhibits the activity of both SirT1 and SirT2 (by 80% at 100 and 25 µM, respectively), while its structural analogue Sirtinol (Cat. Nos. 566320 and 566321), at 100 µM concentration, inhibits SirT2 only by up to 60% and is of no effect against SirT1. Salermide is also shown to be at least 2-fold more potent than Sirtinol (both at 100 µM) in killing leukemia KG1A and lymphoma Raji cultures. |
| Catalogue Number | 566330 |
| Brand Family | Calbiochem® |
| Synonyms | N-(3-((2-Hydroxynaphthalen-1-ylmethylene)-amino)-phenyl)-2-phenyl-propionamide, SIRT1 Inhibitor VI, SIRT2 Inhibitor VIII |
| References | |
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| References | Lara, E., et al. 2009. Oncogene 28, 781. |
| Product Information | |
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| CAS number | 1105698-15-4 |
| Form | Yellow solid |
| Hill Formula | C₂₆H₂₂N₂O₂ |
| Chemical formula | C₂₆H₂₂N₂O₂ |
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| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥95% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Référence | GTIN |
| 566330-10MG | 04055977191462 |
Documentation
SIRT1/2 Inhibitor VIII, Salermide - CAS 1105698-15-4 - Calbiochem FDS
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SIRT1/2 Inhibitor VIII, Salermide - CAS 1105698-15-4 - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
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| 566330 |
Références bibliographiques
| Aperçu de la référence bibliographique |
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| Lara, E., et al. 2009. Oncogene 28, 781. |
Fiche technique
| Titre |
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| SIRTainty™ Class III HDAC Assay |