565840 Sigma-AldrichSHIP2 Inhibitor, AS1938909 - Calbiochem
The SHIP2 Inhibitor, AS1938909 controls the biological activity of SHIP2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The SHIP2 Inhibitor, AS1938909 controls the biological activity of SHIP2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<SHIP2 Inhibitor, AS1938909 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: 3-(2,4-Dichlorobenzyl)oxy]-N-(2,6-difluorobenzyl)thiophene-2-carboxamide, SH2 domain-containing inositol 5ʹ-phosphatase 2 (SHIP2) Inhibitor, AS1938909
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Aperçu
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Tableau de caractéristiques principal
| Empirical Formula |
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| C₁₉H₁₃Cl₂F₂NO₂S |
Products
| Référence | Conditionnement | Qté | |
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| 565840-10MG | Flacon en verre | 10 mg |
| Description | |
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| Overview | A cell-permeable thiophenecarboxamide compound that is shown to increase glucose metabolism and activate intracellular insulin signaling. Acts as a potent, competitive and reversible inhibitor of SHIP2 activity (Ki = 0.44 µM for hSHIP2) with moderate to excellent selectivity over SHIP1 and other related phosphatases (IC50 = 0.18, 0.57, 21, > 50, > 50 and > 50 µM for mSHIP2, hSHIP2, hSHIP1, hPTEN, h-synaptojanin and h-myotubularin, respectively). Elevates insulin-induced pAkt-Ser473 levels and enhances glucose transporter GLUT1 mRNA expression in L6 myotubes. SHIP1 Inhibitor, 3AC is also available (Cat. No. 565835). |
| Catalogue Number | 565840 |
| Brand Family | Calbiochem® |
| Synonyms | 3-(2,4-Dichlorobenzyl)oxy]-N-(2,6-difluorobenzyl)thiophene-2-carboxamide, SH2 domain-containing inositol 5ʹ-phosphatase 2 (SHIP2) Inhibitor, AS1938909 |
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| References | Suwa, A., et al. 2010. Eur. J. Pharmacol. 642, 177. Suwa, A., et al. 2009. Br. J. Pharmacol. 158, 879. |
| Product Information | |
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| Form | Off-white solid |
| Hill Formula | C₁₉H₁₃Cl₂F₂NO₂S |
| Chemical formula | C₁₉H₁₃Cl₂F₂NO₂S |
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| Quality Level | MQ100 |
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| Purity | ≥95% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Référence | GTIN |
| 565840-10MG | 04055977191936 |
Documentation
SHIP2 Inhibitor, AS1938909 - Calbiochem FDS
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SHIP2 Inhibitor, AS1938909 - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
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| 565840 |
Références bibliographiques
| Aperçu de la référence bibliographique |
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| Suwa, A., et al. 2010. Eur. J. Pharmacol. 642, 177. Suwa, A., et al. 2009. Br. J. Pharmacol. 158, 879. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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