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559410 SB 290157 - CAS 1140525-25-2 - Calbiochem

SB 290157, CAS 1140525-25-2, is a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (IC50 = 200 nM). Does not antagonize C5aR or other chemotactic GPCRs.

SB 290157 - CAS 1140525-25-2 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N²-[(2,2-Diphenylethoxy)acetyl]-L-arginine, TFA

Primary Target: C3a receptor
559410
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
1140525-25-2C₂₂H₂₈N₄O₄ · CF₃CO₂H

Products

RéférenceConditionnement Qté
559410-10MG Ampoule plast. 10 mg
Description
OverviewA non-peptide that acts as a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (IC50 = 200 nM). Does not antagonize C5aR or other chemotactic G-protein-coupled receptors. Blocks C3a-induced internalization of C3aR in human neutrophils and C3a-induced Ca2+ mobilization in basophilic leukemia RBL-2H3 cells expressing murine, guinea pig, or human C3aR (IC50 = 7, 12.5, and 27.7 nM, respectively). Also blocks C3a-mediated ATP release from Guinea pig platelets (IC50 = 30 nM). Exhibits anti-inflammatory properties. Supplied as a trifluoroacetate salt.
Catalogue Number559410
Brand Family Calbiochem®
SynonymsN²-[(2,2-Diphenylethoxy)acetyl]-L-arginine, TFA
References
ReferencesAmes, R.S., et al. 2001. J. Immunol. 166, 6341.
Product Information
CAS number1140525-25-2
ATP CompetitiveN
FormLyophilized
Hill FormulaC₂₂H₂₈N₄O₄ · CF₃CO₂H
Chemical formulaC₂₂H₂₈N₄O₄ · CF₃CO₂H
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationSB 290157, CAS 1140525-25-2, is a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (IC50 = 200 nM). Does not antagonize C5aR or other chemotactic GPCRs.
Biological Information
Primary TargetC3a receptor
Primary Target IC<sub>50</sub>200 nM against the anaphylatoxin C3a receptor; 7, 12.5, and 27.7 nM, in blocking C3a-induced internalization of C3aR in human neutrophils and C3a-induced Ca2+ mobilization in basophilic leukemia RBL-2H3 cells expressing murine, guinea pig, or human C3aR
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Do not reuse solutions diluted in physiological buffers.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
559410-10MG 04055977268140

Documentation

SB 290157 - CAS 1140525-25-2 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

SB 290157 - CAS 1140525-25-2 - Calbiochem Certificats d'analyse

TitreNuméro de lot
559410

Références bibliographiques

Aperçu de la référence bibliographique
Ames, R.S., et al. 2001. J. Immunol. 166, 6341.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-April-2011 RFH
SynonymsN²-[(2,2-Diphenylethoxy)acetyl]-L-arginine, TFA
DescriptionA non-peptide with anti-inflammatory properties that acts as a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (C3aR; IC50 = 200 nM). Does not antagonize C5aR or other chemotactic G-protein coupled receptors. Blocks C3a-induced internalization of C3aR in human neutrophils and C3a-induced Ca2+ mobilization in basophilic leukemia RBL-2H3 cells expressing murine, guinea pig, or human C3aR (IC50 = 7, 12.5, and 27.7 nM, respectively). Also blocks C3a-mediated ATP release from guinea pig platelets (IC50 = 30 nM).
FormLyophilized
Intert gas (Yes/No) Packaged under inert gas
CAS number1140525-25-2
Chemical formulaC₂₂H₂₈N₄O₄ · CF₃CO₂H
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Do not reuse solutions diluted in physiological buffers.
Toxicity Standard Handling
ReferencesAmes, R.S., et al. 2001. J. Immunol. 166, 6341.