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14-527M Ros Protein, active, 250 µg

Active, N-terminal His6-tagged recombinant human Ros residues 1883-end, for use in Kinase Assays.

Ros Protein, active, 250 µg : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
14-527M
250 µg  Also available in 10 μg size (cat#14-527) and in bulk (cat# 14-527-K).
Purchase on Sigma-Aldrich

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Replacement Information
Description
Catalogue Number14-527M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionRos Protein, active, 250 µg
OverviewN-terminal His6-tagged recombinant human Ros residues 1883-end
References
Product Information
Quality LevelMQ100
Applications
ApplicationActive, N-terminal His6-tagged recombinant human Ros residues 1883-end, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Sourceexpressed by baculovirus in Sf21 insect cells
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene SummaryThis proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.
Gene Symbol
  • ROS1
  • MCF3
  • ROS
  • OTTHUMP00000040389
Protein TargetRos
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyTK
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P08922 # This is probably a cell growth or differentiation factor receptor with a tyrosine-protein kinase activity.
SIZE: 2347 amino acids; 263915 Da
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
DISEASE: SwissProt: P08922 # A chromosomal aberration involving ROS1 is found in glioblastoma multiform (GBM). An homozygous deletion in chromosome 6q21 results in expression of a GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.
SIMILARITY: SwissProt: P08922 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 9 fibronectin type-III domains. & Contains 1 protein kinase domain.
Molecular Weight53.4kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assuranceroutinely evaluated by phosphorylation of KKKSPGEYVNIEFG
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-527) and in bulk (cat# 14-527-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
14-527M 04053252516016

Produits & Applications associés

Alternative Packsize

Référence Description
14-527 Ros Protein, active, 10 µg

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Catégories

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases