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553514 RAD51 Inhibitor II, RI-1 - Calbiochem

553514
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Aperçu

Tableau de caractéristiques principal

Empirical Formula
C₁₄H₁₁Cl₃N₂O₃

Products

RéférenceConditionnement Qté
553514-10MG Flacon en verre 10 mg
Description
OverviewA cell-permeable 1H-Pyrrole-2,3-dione derivative that covalently binds to RAD51 at Cys319 and irreversibly destabilizes a protein-protein interface that is essential for filament formation and recombinase activity. Stimulates single strand annealing at a 5-30 µM concentration. Inhibits subnuclear RAD51 foci formation following DNA damage without affecting replication protein A. Also, effectively sensitizes cancer cells to mitomycin C (~25 µM) and generate synergistic cell kill in RAD51C mutant cells and with lesser effect on RAD51 complemented cells. Satisfies all four Lipinski rules for predicting drug likeness.
Catalogue Number553514
Brand Family Calbiochem®
Synonyms3-chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione
References
ReferencesBudke, B., et al. 2012. Nucleic Acids Res. 40, 7347.
Product Information
FormBright yellow solid
Hill FormulaC₁₄H₁₁Cl₃N₂O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationRAD51 Inhibitor II, RI-1, CAS 415713-60-9, covalently binds to RAD51 at Cys319 and irreversibly destabilizes a protein-protein interface that is needed for filament formation & recombinase activity.
Biological Information
Primary TargetRAD51
Primary Target IC<sub>50</sub>5-30 µ
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Référence GTIN
553514-10MG 04055977193732