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508514 Psalmotoxin-1 - CAS 316808-68-1 - Calbiochem

A potent proton-gated sodium channel (ASIC1a) channel blocking neurotoxin (IC₅₀ = 0.9 nM) that can distinguish between the two ASIC1 splice variants, ASIC1a and ASIC1b.

Psalmotoxin-1 - CAS 316808-68-1 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: ASIC1a Inhibitor, Psalmotoxin 1

Primary Target: ASIC1a
508514
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
316808-68-1 C₂₀₀H₃₁₂N₆₂O₅₇S₆

Products

RéférenceConditionnement Qté
5085140001 Flacon en verre 20 μg
Description
OverviewA potent proton-gated sodium channel (ASIC1a) channel blocking neurotoxin (IC50 = 0.9 nm) isolated from the Trinidad chevron tarantula. Psalmotoxin-1 (PcTx1) can distinguish between the two ASIC1 splice variants, ASIC1a and ASIC1b. Binding site is blocked when dimerization with ASIC2a or ASIC3.
Catalogue Number508514
Brand Family Calbiochem®
SynonymsASIC1a Inhibitor, Psalmotoxin 1
References
ReferencesQadri, Y. J. et al. 2009. J. Biol. Chem. 284, 17625.
M. Mazzuca, et al. 2007. Nat Neurosci. 10, 943.
Escoubas, P. et al. 2000. J. Biol. Chem. 275, 25116.
Product Information
CAS number316808-68-1
FormColorless semi-solid to viscous liquid
Hill Formula C₂₀₀H₃₁₂N₆₂O₅₇S₆
Chemical formulaC₂₀₀H₃₁₂N₆₂O₅₇S₆
Hygroscopic Hygroscopic
Quality LevelMQ100
Applications
Biological Information
Primary TargetASIC1a
Primary Target IC<sub>50</sub>0.9 nM
Purity≥94% by HPLC
Physicochemical Information
Peptide SequenceEDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT (disulfide bond 3-18, 10-23, 17-33)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
5085140001 04055977262056

Documentation

Psalmotoxin-1 - CAS 316808-68-1 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Références bibliographiques

Aperçu de la référence bibliographique
Qadri, Y. J. et al. 2009. J. Biol. Chem. 284, 17625.
M. Mazzuca, et al. 2007. Nat Neurosci. 10, 943.
Escoubas, P. et al. 2000. J. Biol. Chem. 275, 25116.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-March-2019 JSW
SynonymsASIC1a Inhibitor, Psalmotoxin 1
DescriptionA potent proton-gated sodium channel (ASIC1a) channel blocking neurotoxin (IC50 = 0.9 nm) isolated from the Trinidad chevron tarantula. Psalmotoxin-1 (PcTx1) can distinguish between the two ASIC1 splice variants, ASIC1a and ASIC1b. Binding site is blocked when dimerization with ASIC2a or ASIC3.
FormColorless semi-solid to viscous liquid
CAS number316808-68-1
Chemical formulaC₂₀₀H₃₁₂N₆₂O₅₇S₆
Peptide SequenceEDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT (disulfide bond 3-18, 10-23, 17-33)
Purity≥94% by HPLC
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesQadri, Y. J. et al. 2009. J. Biol. Chem. 284, 17625.
M. Mazzuca, et al. 2007. Nat Neurosci. 10, 943.
Escoubas, P. et al. 2000. J. Biol. Chem. 275, 25116.