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539162 Proteasome Inhibitor II - Calbiochem

The Proteasome Inhibitor II controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Proteasome Inhibitor II - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: (Benzyloxycarbonyl)-Leu-Leu-phenylalaninal, Z-LLF-CHO

Primary Target: MPC
539162
Purchase on Sigma-Aldrich

Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₂₉H₃₉N₃O₅

Products

RéférenceConditionnement Qté
539162-1MG Ampoule plast. 1 mg
539162-5MG Ampoule plast. 5 mg
Description
OverviewA potent, cell-permeable, and reversible proteasome inhibitor. Inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (MPC; Ki = 460 nM). Does not inhibit the peptidyl-glutamyl peptide hydrolyzing activity of MPC even at concentrations of 200 µM. Also blocks the decay of IκB-α and IκB-β proteins in exponentially growing WEHI 231 cells.
Catalogue Number539162
Brand Family Calbiochem®
Synonyms(Benzyloxycarbonyl)-Leu-Leu-phenylalaninal, Z-LLF-CHO
References
ReferencesSchauer, S.L., et al. 1998. J. Immunol. 160, 4398.
Orlowski, M., et al. 1997. Biochemistry 36, 13946.
Orlowski, M., et al. 1993. Biochemistry 32, 1563.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
Hill FormulaC₂₉H₃₉N₃O₅
Chemical formulaC₂₉H₃₉N₃O₅
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetMPC
Primary Target K<sub>i</sub>460 nM against the pituitary multicatalytic proteinase complex (MPC)
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Leu-Leu-Phe-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
539162-1MG 04055977269451
539162-5MG 04055977269468

Documentation

Proteasome Inhibitor II - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Proteasome Inhibitor II - Calbiochem Certificats d'analyse

TitreNuméro de lot
539162

Références bibliographiques

Aperçu de la référence bibliographique
Schauer, S.L., et al. 1998. J. Immunol. 160, 4398.
Orlowski, M., et al. 1997. Biochemistry 36, 13946.
Orlowski, M., et al. 1993. Biochemistry 32, 1563.

Brochure

Titre
Caspases and other Apoptosis Related Tools Brochure
Proteasomes Technical Bulletin
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-September-2008 RFH
Synonyms(Benzyloxycarbonyl)-Leu-Leu-phenylalaninal, Z-LLF-CHO
DescriptionA potent and cell-permeable proteasome inhibitor. Inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (MPC; Ki = 460 nM). Does not inhibit the peptidylglutamyl-peptide hydrolyzing (PGPH) activity of MPC even at concentrations of 200 µM. Also blocks the decay of IκB-α and IκB-β proteins in exponentially growing WEHI 231 cells.
FormWhite lyophilized solid
Chemical formulaC₂₉H₃₉N₃O₅
Peptide SequenceZ-Leu-Leu-Phe-CHO
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from moisture
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.
Toxicity Standard Handling
ReferencesSchauer, S.L., et al. 1998. J. Immunol. 160, 4398.
Orlowski, M., et al. 1997. Biochemistry 36, 13946.
Orlowski, M., et al. 1993. Biochemistry 32, 1563.