539160 Sigma-AldrichProteasome Inhibitor I - Calbiochem
The Proteasome Inhibitor I controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
More>> The Proteasome Inhibitor I controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Less<<Proteasome Inhibitor I - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: PSI
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Aperçu
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Tableau de caractéristiques principal
| Empirical Formula |
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| C₃₂H₅₀N₄O₈ |
Products
| Référence | Conditionnement | Qté | |
|---|---|---|---|
| 539160-1MG | Ampoule plast. | 1 mg | |
| 539160-5MG | Ampoule plast. | 5 mg |
| Description | |
|---|---|
| Overview | A cell-permeable, reversible inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells. Causes the accumulation of ubiquitinated proteins in neuronal cells. Prevents the activation of NF-κB in response to TNF-α and Okadaic Acid (Cat. No. 495604) through inhibition of IκB-α degradation. A 50 mM (5 mg/162 µl) solution of Proteasome Inhibitor I (Cat. No. 539161) in DMSO is also available. |
| Catalogue Number | 539160 |
| Brand Family | Calbiochem® |
| Synonyms | PSI |
| Product Information | |
|---|---|
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₃₂H₅₀N₄O₈ |
| Chemical formula | C₃₂H₅₀N₄O₈ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells |
| Purity | ≥90% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Peptide Sequence | Z-Ile-Glu(OtBu)-Ala-Leu-CHO |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Référence | GTIN |
| 539160-1MG | 04055977269420 |
| 539160-5MG | 04055977269437 |
Documentation
Proteasome Inhibitor I - Calbiochem FDS
| Titre |
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Proteasome Inhibitor I - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
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| 539160 |
Références bibliographiques
| Aperçu de la référence bibliographique |
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| Griscavage, J.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3308. Mori, S., et al. 1995. J. Biol. Chem. 270, 29447. Figueiredo-Pereira, M.E., et al. 1994. J. Neurochem. 63, 1578. Traenckner, E.B., et al. 1994. EMBO J. 13, 5433. |
Brochure
| Titre |
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| Caspases and other Apoptosis Related Tools Brochure |
| Proteasomes Technical Bulletin |
Citations
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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